2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
1996
The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis
Kashgarian M. The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis. Renal Failure 1996, 18: 765-773. PMID: 8903091, DOI: 10.3109/08860229609047705.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusLong-term outcomesCourse of diseaseWorld Health OrganizationMorphologic modalitiesKidney biopsyRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationImmune responseIndividual patientsSame patientBiopsy interpretationNephritisPatientsBiopsySemiquantitative assessmentDifferent patientsHealth Organization
1994
The benefit of early treatment with immunosuppressive agents in lupus nephritis.
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The benefit of early treatment with immunosuppressive agents in lupus nephritis. The Journal Of Rheumatology 1994, 21: 2046-51. PMID: 7869308.Peer-Reviewed Original ResearchConceptsHour urinary protein excretionUrinary protein excretionLead-time biasRenal biopsyLupus nephritisRenal insufficiencyRenal involvementSerum creatinineProtein excretionImmunosuppressive agentsEarly treatmentHigh-dose prednisoneLupus renal involvementSubsequent renal insufficiencyTime biasFirst renal biopsySelection biasDose prednisoneTubulointerstitial indexRenal diseaseLongterm prognosisImmunosuppressive drugsEffect of durationBiopsySignificant associationThe Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictors
1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern
1992
Can Experienced Clinicians Predict the Outcome of Lupus Nephritis?
Esdaile J, Mackenzie T, Barré P, Danoff D, Kirk Osterland C, Somerville P, Quintal H, Kashgarian M, Suissa S. Can Experienced Clinicians Predict the Outcome of Lupus Nephritis? Lupus 1992, 1: 205-214. PMID: 1301984, DOI: 10.1177/096120339200100403.Peer-Reviewed Original ResearchClinical significance of renal biopsy in subacute lupus erythematosus
Kashgarian M. Clinical significance of renal biopsy in subacute lupus erythematosus. Transfusion And Apheresis Science 1992, 13: 135-144. PMID: 10148125, DOI: 10.1016/0955-3886(92)90164-c.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusSubacute lupus erythematosusCourse of illnessLong-term courseWorld Health OrganizationLupus nephropathyMorphologic modalitiesRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationClinical significanceImmune responseIndividual patientsSame patientBiopsy interpretationPatientsNephritisSemiquantitative assessmentTerm course
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patientsPredictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy
ESDAILE J, FEDERGREEN W, QUINTAL H, SUISSA S, HAYSLETT J, KASHGARIAN M. Predictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy. QJM 1991, 81: 907-918. DOI: 10.1093/oxfordjournals.qjmed.a068639.Peer-Reviewed Original ResearchLupus nephritisRenal biopsySerum creatinineClinical prediction modelBiopsy variablesPrognosis of lupus nephritisDiffuse proliferative lupus nephritisProliferative lupus nephritisDiffuse proliferative nephritisTime of biopsySubepithelial electron-dense depositsActivity index scoreShort-term prognosisBiopsy informationLaboratory predictorsPlatelet countRenal injuryTubulointerstitial scoresProliferative nephritisUnivariate analysisElectron-dense depositsBiopsyCoexisting illnessesNephritisUrinary protein
1989
The Clinical and Renal Biopsy Predictors of Long-term Outcome in Lupus Nephritis: A Study of 87 Patients and Review of the Literature
ESDAILE J, LEVINTON C, FEDERGREEN W, HAYSLETT J, KASHGARIAN M. The Clinical and Renal Biopsy Predictors of Long-term Outcome in Lupus Nephritis: A Study of 87 Patients and Review of the Literature. QJM 1989, 72: 779-833. DOI: 10.1093/oxfordjournals.qjmed.a068371.Peer-Reviewed Original ResearchDuration of renal diseasePresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseRenal insufficiencyRenal failurePrognostic markerClinical modelMarker of immunological activityRenal systemic lupus erythematosusPredictor of long-term outcomeMarkers of disease severityUrinary excretion of proteinNon-renal SLEImmunologic disease activitySystemic lupus erythematosusPredictors of fatalityExcretion of proteinRenal severityConsecutive patientsRenal outcomesChronicity indexBiopsy variablesSerum creatinineThe clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature.
Esdaile J, Levinton C, Federgreen W, Hayslett J, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM 1989, 72: 779-833. PMID: 2694209.Peer-Reviewed Original ResearchConceptsPresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseClinical modelRenal insufficiencyRenal failurePrognostic markerRelevant long-term outcomesRenal systemic lupus erythematosusImmunologic disease activityNon-renal SLESystemic lupus erythematosusImportant prognostic markerChronicity indexRenal outcomesRenal severityDisease activityNew predictive informationSerum creatinineConsecutive patientsLupus erythematosusPrognostic factorsRenal biopsyComorbid conditions
1980
The significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1977
THE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS
Domoto D, Siegel N, Kashgarian M. THE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS. Pediatric Research 1977, 11: 549-549. DOI: 10.1203/00006450-197704000-01075.Peer-Reviewed Original Research