2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1997
Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion
Sangan P, Rajendran V, Mann A, Kashgarian M, Binder H. Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion. American Journal Of Physiology 1997, 272: c685-c696. PMID: 9124313, DOI: 10.1152/ajpcell.1997.272.2.c685.Peer-Reviewed Original ResearchConceptsDietary K depletionDistal colonNA depletionK-ATPase activityProximal colonLarge intestineRat distal colonActive K absorptionK-ATPaseRenal collecting ductsDietary NaK-ATPase expressionK-ATPase isoformsK depletionRat colonCollecting ductsOuter medullaColonProtein expressionProtein levelsKidneyPolyclonal antibodiesIntestineDuctMRNA
1993
Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy
Hwang S, Harris H, Otuechere G, Yalla S, Sullivan M, Kashgarian M, Benos D, Kleyman T, Zeidel M. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. American Journal Of Physiology 1993, 264: f808-f815. PMID: 8388652, DOI: 10.1152/ajprenal.1993.264.5.f808.Peer-Reviewed Original ResearchConceptsObstructed kidneysIMCD cellsUntreated control kidneysOuabain-insensitive QO2Ouabain-sensitive QO2Urinary obstructionObstructive nephropathyControl kidneysControl animalsControl groupKidneyMonoclonal antibodiesMarked reductionDuct cellsAlpha 1Cellular mechanismsSignificant differencesChannel proteinsReabsorptionAntibodiesOxygen consumption studiesTransport defectRabbitsCellsImmunoblotTransport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1992
THE EFFECT OF CYCLOSPORINE ADMINISTRATION ON THE CELLULAR DISTRIBUTION AND CONTENT OF CYCLOPHILIN 1
McDONALD M, ARDITO T, MARKS W, KASHGARIAN M, LORBER M. THE EFFECT OF CYCLOSPORINE ADMINISTRATION ON THE CELLULAR DISTRIBUTION AND CONTENT OF CYCLOPHILIN 1. Transplantation 1992, 53: 460-466. PMID: 1472259, DOI: 10.1097/00007890-199202010-00037.Peer-Reviewed Original ResearchConceptsCyclosporine metabolitesDays of CsAUntreated Wistar ratsPrevious immunohistochemical analysisCyclosporine administrationCsA therapyLymph nodesWistar ratsImmunohistochemical analysisCYP contentBiologic effectsMitochondria-endoplasmic reticulumQuantitative immunofluorescenceNuclear stainingGeneralized increaseCYP interactionsCsAEnzyme peptidyl-prolyl cis-trans isomeraseCellular distributionIleumKidneyUntreated controlsLiverBiological effectsConfocal microscopy
1989
Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase
Van Waarde A, Stromski M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. American Journal Of Physiology 1989, 256: f298-f305. PMID: 2537026, DOI: 10.1152/ajprenal.1989.256.2.f298.Peer-Reviewed Original ResearchConceptsRenal ischemic insultResidual nucleotide poolMin of ischemiaRenal ATP contentFunctional recoveryIschemic injuryIschemic insultKidney functionRenal ischemiaIntramuscular injectionUntreated ratsRapid initial recoveryATP restorationRat kidneyRenal ATPIschemiaInitial recoveryKidneyRatsATP contentInsultFunctional consequencesNucleotide poolMagnetic resonanceAMPCP
1986
Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism
Jaeger P, Jones W, Hayslett J, Kashgarian M, Segre G. Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism. Advances In Experimental Medicine And Biology 1986, 208: 379-382. PMID: 3565154, DOI: 10.1007/978-1-4684-5206-8_47.Peer-Reviewed Original Research
1982
The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study
Biemesderfer D, Stanton B, Kashgarian M, Giebisch G. The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study. Microscopy And Microanalysis 1982, 40: 170-171. DOI: 10.1017/s0424820100053541.Peer-Reviewed Original Research
1981
Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion
Siegel N, Upadhyaya K, Kashgarian M. Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion. Kidney International 1981, 20: 691-694. PMID: 7334741, DOI: 10.1038/ki.1981.197.Peer-Reviewed Original ResearchConceptsUnilateral ureteral occlusionBilateral ureteral occlusionContralateral kidneyUreteral occlusionRenal functionAdaptive changesCompensatory changesObstructive renal injuryInfusion of indomethacinRelease of obstructionRenal hemodynamicsRenal injuryPattern of recoveryObstructive nephropathyPathophysiologic alterationsRenal massesUnoperated kidneysKidneyOcclusionAdaptive alterationsHemodynamicsControl organsIndomethacinAlterationsPresent study
1974
SHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT
SCHIFF M, GOFFINET J, HENDLER E, RUDDLE N, Kashgarian M, LYTTON B. SHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT. Transplantation 1974, 17: 580-583. PMID: 4208389, DOI: 10.1097/00007890-197406000-00006.Peer-Reviewed Original ResearchConceptsShwartzman reactionDiffuse intravascular coagulationIdentical sibling donorsEvidence of sensitizationAntigen mismatchesRenal allograftsIntravascular coagulationKidney transplantSibling donorsNegative bacteremiaHistological examinationSkin transplantationIrreversible cessationSame donorTransplantAllograftsPatientsTransplantationKidneyBacteremiaSteroidsDonorsAntibodiesSensitizationCessation
1971
Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960
Du V. Florey C, Kessner D, Kashgarian M, Senter M. Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960. Journal Of Clinical Epidemiology 1971, 24: 71-77. PMID: 5568747, DOI: 10.1016/0021-9681(71)90060-9.Peer-Reviewed Original Research
1959
Effect of acute potassium deficiency on susceptibility to infection with particular reference to the kidney.
Carone F, Kashgarian M, Epstein F. Effect of acute potassium deficiency on susceptibility to infection with particular reference to the kidney. The Yale Journal Of Biology And Medicine 1959, 32: 100-8. PMID: 13807844, PMCID: PMC2604070.Peer-Reviewed Original Research