1988
Beneficial effect of thyroxin in the treatment of ischemic acute renal failure
Sutter P, Thulin G, Stromski M, Ardito T, Gaudio K, Kashgarian M, Siegel N. Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatric Nephrology 1988, 2: 1-7. PMID: 2856365, DOI: 10.1007/bf00870370.Peer-Reviewed Original ResearchConceptsAcute renal failureIschemic acute renal failureRenal failureIschemic controlsNormal salineSaline-treated ischemic controlsBeneficial effectsBetter kidney functionDose of T4Min of reflowT4-treated ratsEffect of thyroxinRenal functionKidney functionNS animalsRenal ischemiaInulin clearanceSaline controlsDay 3Day 7IschemiaT4 animalsRenal ATPCellular mechanismsSignificant increase
1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENa
1982
Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2
Gaudio K, Taylor M, Chaudry I, Kashgarian M, Siegel N. Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2. Kidney International 1982, 22: 13-20. PMID: 7120752, DOI: 10.1038/ki.1982.126.Peer-Reviewed Original ResearchConceptsClearance of inulinSingle nephron functionATP-MgCl2Proximal tubular pressureNephron functionTubular pressureBeneficial effectsRenal artery ischemiaSaline-treated animalsSaline-treated ratsCourse of recoveryGroups of animalsPostischemic administrationArtery ischemiaPattern of recoveryCIN 1Postischemic infusionInitial insultInulin clearanceInitial improvementControl animalsMost epithelial cellsEnhanced recoveryWhole kidneyTubular fluid