On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
Cho B, Jung Y, DeMario V, Lau E, Podlasek S, Grant M, Gehrie E, Frank S. On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study. Transfusion 2019, 59: 2678-2684. PMID: 31121073, DOI: 10.1111/trf.15355.Peer-Reviewed Original ResearchConceptsUrgent reversalLabel useMortality rateFour-factor prothrombin complex concentrateAcute major bleedingVitamin K antagonistsProthrombin complex concentrate useProthrombin complex concentrateOff-label useCoagulation factor deficienciesHospital mortalityMajor bleedingK antagonistsPatient characteristicsClinical outcomesBlood utilizationExpensive treatment optionsLabel indicationsSingle institutionTreatment optionsComplex concentrateObservational studyFactor deficiencyInvasive proceduresOff labelDischarge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery
Cho B, DeMario V, Grant M, Hensley N, Brown C, Hebbar S, Mandal K, Whitman G, Frank S. Discharge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery. Anesthesia & Analgesia 2019, 128: 342-348. PMID: 30059402, PMCID: PMC6533067, DOI: 10.1213/ane.0000000000003671.Peer-Reviewed Original ResearchConceptsDischarge Hb levelsDischarge hemoglobin levelsReadmission ratesHb levelsPatient characteristicsHemoglobin levelsMultivariable analysisBlood utilizationCoronary artery bypass surgeryCertain patient comorbiditiesRestrictive transfusion strategyCharlson Comorbidity IndexCoronary artery bypassArtery bypass surgeryLarge randomized trialsRisk-adjusted oddsSimilar patient characteristicsLow Hb levelsCABG patientsDischarge HbPreoperative comorbiditiesArtery bypassComorbidity indexBypass surgeryPatient comorbidities