2020
Zinc supplement ameliorates phthalates-induced reproductive toxicity in male rats
Gao HT, Di QN, Qian LL, Lu L, Li RX, Cao WX, Xu Q. Zinc supplement ameliorates phthalates-induced reproductive toxicity in male rats. Chemosphere 2020, 246: 125828. PMID: 31927381, DOI: 10.1016/j.chemosphere.2020.125828.Peer-Reviewed Original ResearchConceptsZinc supplementsMale ratsReproductive toxicityReproductive functionProtein expressionSteroidogenic proteinsSub-chronic exposureMale reproductive functionMale reproductive toxicityPathological examinationRat testicular cellsRatsTesticular cellsLHHealth risksExposureSerumSupplementsUrineToxicityMixture exposureTestisAlterationsExpressionToxicity evaluation
2017
Disruption of the gaa Gene in Zebrafish Fails to Generate the Phenotype of Classical Pompe Disease
Wu J, Yang Y, Sun C, Sun S, Li Q, Yao Y, Fei F, Lu L, Chang Z, Zhang W, Wang X, Luo F. Disruption of the gaa Gene in Zebrafish Fails to Generate the Phenotype of Classical Pompe Disease. DNA And Cell Biology 2017, 36: 10-17. PMID: 28045567, DOI: 10.1089/dna.2016.3459.Peer-Reviewed Original ResearchConceptsGAA mRNAFrameshift mutationEnzymatic activityGene expression changesGAA geneSpecies-specific differencesPresence of autophagosomesGlycogen accumulationMutant zebrafishGAA enzymatic activityWT zebrafishZebrafish modelDays postfertilizationExpression changesZebrafishDifferent speciesPhenotypic changesAdult stageLysosomal glycogen accumulationGlycogen storage disease type IIStorage disease type IIGenesProtein levelsProtein expressionMutants