Lack of vimentin impairs endothelial differentiation of embryonic stem cells
Boraas L, Ahsan T. Lack of vimentin impairs endothelial differentiation of embryonic stem cells. Scientific Reports 2016, 6: 30814. PMID: 27480130, PMCID: PMC4969593, DOI: 10.1038/srep30814.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDBiomarkersCadherinsCell DifferentiationCell ProliferationCells, CulturedEmbryoid BodiesEndothelial CellsGene Knockout TechniquesMiceMouse Embryonic Stem CellsReceptor, TIE-2Vascular Endothelial Growth Factor Receptor-2VimentinConceptsEmbryonic stem cellsEmbryoid bodiesKnockout embryonic stem cellsWild-type embryonic stem cellsStem cellsEndothelial phenotypeCell typesWT EBsSpecification pathwayCytoskeletal filament vimentinGene expressionSpontaneous differentiationPluripotency markersEndothelial differentiationProper functionVE-cadherinPresence of vimentinPhenotypeProtein expressionDifferentiationDecreased expressionExpressionEndothelial cellsCellsAdult mice