2016
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells
Xu L, Kittrell S, Yeudall WA, Yang H. Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells. Nanomedicine 2016, 11: 2959-2973. PMID: 27781559, PMCID: PMC5144492, DOI: 10.2217/nnm-2016-0244.Peer-Reviewed Original ResearchConceptsNeck cancer cellsCancer cellsFR-dependent mannerEnhanced gene expressionGene expressionSame binding siteCellular uptakeGenesDelivery of genesBinding sitesHigh expressionFree FASuitable vectorPlasmidDNA plasmidsCellsTransfection resultsExpressionTransfection efficiencySelective uptakeUptakeFolate receptorHigh levelsVectorFA
2012
Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro
Zhang X, Bai Q, Xu L, Kakiyama G, Pandak WM, Zhang Z, Ren S. Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro. AJP Gastrointestinal And Liver Physiology 2012, 303: g344-g355. PMID: 22679001, PMCID: PMC3423104, DOI: 10.1152/ajpgi.00403.2011.Peer-Reviewed Original ResearchConceptsLiver X receptorMouse liver tissueLiver tissueSulfotransferase 2B1bLiver proliferationPCNA-positive cellsPrimary rat hepatocytesCell nuclear antigenOxysterol sulfotransferaseWestern blot analysisCell cycle regulatory gene expressionProliferation gene expressionTime-dependent mannerGene expressionC57BL/6 miceQuantitative real-time PCRReal-time PCRLXR activationDouble immunofluorescenceLabeling indexSelective cholesterolAntiproliferative factorPCNA expressionLipid metabolismIncreased expression
2008
25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway
Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. AJP Endocrinology And Metabolism 2008, 295: e1369-e1379. PMID: 18854425, PMCID: PMC2603552, DOI: 10.1152/ajpendo.90555.2008.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCell ProliferationCells, CulturedCholesterol EstersDNA-Binding ProteinsDose-Response Relationship, DrugGene Expression RegulationHumansHydroxycholesterolsLipid MetabolismLipidsLiver X ReceptorsMacrophagesModels, BiologicalOrphan Nuclear ReceptorsReceptors, Cytoplasmic and NuclearSignal TransductionSterol Regulatory Element Binding Protein 1SulfatesConceptsLXR/SREBPFatty acid synthaseSREBP-1Lipid metabolismFatty acid synthetic pathwayKey transcriptional regulatorMacrophage lipid metabolismImportant regulatory moleculesTHP-1-derived macrophagesMature proteinTranscriptional regulatorsAcetyl-CoA carboxylase 1MRNA levelsFAS mRNA levelsKey proteinsGene expressionRegulatory moleculesHuman THP-1-derived macrophagesAcid synthaseSREBPLipid synthesisOxysterol sulfationLXR ligandsCarboxylase 1Cell proliferation