2014
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphateIntracellular Ca2Prefrontal cortical pyramidal neuronsReceptor-mediated intracellular Ca2Regulation of cAMPPrefrontal cortical slicesCortical pyramidal neuronsDISC1 functionMajor depressive disorderPyramidal neuron activityPatch-clamp recordingsTRPC channel activityDISC1 disruptionPrefrontal cortex activityPyramidal neuronsCortical slicesDepressive disorderAdult ratsIntracellular calcium wavesSustained depolarizationViral knockdownNeuron activityBipolar disorderMental disordersCAMP generation
1998
When, where, and how much? Expression of the Kv3.1 potassium channel in high‐frequency firing neurons
Gan L, Kaczmarek L. When, where, and how much? Expression of the Kv3.1 potassium channel in high‐frequency firing neurons. Developmental Neurobiology 1998, 37: 69-79. PMID: 9777733, DOI: 10.1002/(sici)1097-4695(199810)37:1<69::aid-neu6>3.0.co;2-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAuditory brain stem neuronsVoltage-dependent potassium currentsBrain stem neuronsHigh-frequency firing neuronsKv3.1 potassium channelStem neuronsKv3.1 potassium channel geneLong-term regulationSynaptic inputsPotassium currentPotassium channel genesNeuronsPotassium channelsKv3.1 geneKv3.1 subunitsFiring neuronsHigh frequencyChannel genesCurrent knowledgeChannels altersTranscriptional mechanismsCell-type specificityExpressionGene transcriptionExtrinsic factors
1997
Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion
Jonas E, Knox R, Smith T, Wayne N, Connor J, Kaczmarek L. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385: 343-346. PMID: 9002519, DOI: 10.1038/385343a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoquinonesCalciumCalcium ChannelsCells, CulturedCyclic AMPEndoplasmic ReticulumHeparinInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinInvertebrate HormonesLactams, MacrocyclicNeuronsNeuropeptidesProtein-Tyrosine KinasesQuinonesReceptors, Cytoplasmic and NuclearRifabutinThapsigarginConceptsIntracellular Ca2Neuropeptide secretionSpontaneous action potentialsEffect of insulinSecretion of neuropeptidesTyrosine kinase receptorsAcute riseBag cell neuronsDistal tipNeuronal dischargeNeuronal Ca2Distinct intracellular poolsCell neuronsAction potentialsCyclic AMP analogueInsulinNeuropeptidesInsulin receptorKinase receptorsSecretionPresumed siteNeuronsIntracellular poolMitochondrial Ca2Receptors
1996
Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗)
Gan L, Perney T, Kaczmarek L. Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗). Journal Of Biological Chemistry 1996, 271: 5859-5865. PMID: 8621457, DOI: 10.1074/jbc.271.10.5859.Peer-Reviewed Original Research3T3 Cells8-Bromo Cyclic Adenosine MonophosphateAnimalsBase SequenceBinding SitesBucladesineCell DifferentiationChloramphenicol O-AcetyltransferaseCloning, MolecularCyclic AMPDNA PrimersDNA, ComplementaryFibroblastsGene ExpressionGenomic LibraryIonomycinKineticsMiceMolecular Sequence DataNeuronsNeuropeptidesPC12 CellsPlasmidsPodophyllinPodophyllotoxinPotassium ChannelsPotassium Channels, Voltage-GatedPromoter Regions, GeneticRatsRecombinant ProteinsRegulatory Sequences, Nucleic AcidRestriction MappingSequence DeletionShaw Potassium ChannelsTransfection
1995
Modulation of the inactivation of voltage-dependent potassium channels by cAMP
Chung S, Kaczmarek L. Modulation of the inactivation of voltage-dependent potassium channels by cAMP. Journal Of Neuroscience 1995, 15: 3927-3935. PMID: 7751955, PMCID: PMC6578223, DOI: 10.1523/jneurosci.15-05-03927.1995.Peer-Reviewed Original Research
1994
Cyclic AMP modulates fast axonal transport in aplysia bag cell neurons by increasing the probability of single organelle movement
Azhderian EM, Hefner D, Lin C, Kaczmarek LK, Forscher P. Cyclic AMP modulates fast axonal transport in aplysia bag cell neurons by increasing the probability of single organelle movement. Neuron 1994, 12: 1223-1233. PMID: 7516686, DOI: 10.1016/0896-6273(94)90439-1.Peer-Reviewed Original ResearchThe minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes
Blumenthal E, Kaczmarek L. The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes. Journal Of Neuroscience 1994, 14: 3097-3105. PMID: 7514215, PMCID: PMC6577436, DOI: 10.1523/jneurosci.14-05-03097.1994.Peer-Reviewed Original ResearchConceptsN-terminal domainMinK proteinPlasma membraneInjected mRNAXenopus oocytesMinK potassium channelsFunctional potassium channelsPotassium channelsAmino acid epitopeProtein sequencesLevels of proteinMink genesLive oocytesIntracellular cAMP levelsKinetics of activationProteinOocytesMinK mRNANonfunctional formMRNASurface expressionRNAMinK currentsMRNA levelsCAMP levels
1992
Recruitment of Ca2+ channels by protein kinase C during rapid formation of putative neuropeptide release sites in isolated Aplysia neurons
Knox R, Quattrocki E, Connor J, Kaczmarek L. Recruitment of Ca2+ channels by protein kinase C during rapid formation of putative neuropeptide release sites in isolated Aplysia neurons. Neuron 1992, 8: 883-889. PMID: 1316764, DOI: 10.1016/0896-6273(92)90202-o.Peer-Reviewed Original ResearchModulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytes
Blumenthal E, Kaczmarek L. Modulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytes. Journal Of Neuroscience 1992, 12: 290-296. PMID: 1370322, PMCID: PMC6575684, DOI: 10.1523/jneurosci.12-01-00290.1992.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAmino Acid SequenceAnimalsCell MembraneCyclic AMPFemaleGene ExpressionHumansMembrane PotentialsMembrane ProteinsMolecular Sequence DataMutagenesis, Site-DirectedOocytesPhosphorylationPotassium ChannelsPotassium Channels, Voltage-GatedProgesteroneProtein Kinase InhibitorsProtein KinasesRatsRNATransfectionXenopus laevisConceptsMinK proteinCAMP-dependent protein kinasePotential phosphorylation sitesXenopus oocytesCAMP levelsPhosphorylation sitesProtein kinasePlasma membraneKinase activityChannel proteinsIntracellular cAMP levelsProtein inhibitorProteinKinasePotassium channelsOocytesVoltage-dependent potassium currentsIsK
1990
Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons
Loechner K, Kaczmarek L. Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons. Brain Research 1990, 532: 1-6. PMID: 2178030, DOI: 10.1016/0006-8993(90)91733-w.Peer-Reviewed Original ResearchConceptsVoltage-dependent potassium currentsCyclic AMP levelsBag cell neuronsPotassium currentCell neuronsAMP levelsAlpha-BCPWhole-cell patch-clamp techniqueCell patch-clamp techniqueBag cell afterdischargeTransient voltage-dependent potassium currentPatch-clamp techniqueDelayed potassium currentPharmacologic elevationClamp techniqueOutward currentsAfterdischargesNeuronsCell peptidesAplysia neuronsNeuropeptidesBeta-BCPConsistent effectSecond messengerAlphaCyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia
Azhderian E, Kaczmarek L. Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia. Journal Of Molecular Neuroscience 1990, 2: 61-70. PMID: 1964064, DOI: 10.1007/bf02876912.Peer-Reviewed Original ResearchConceptsBag cell neuronsEgg-laying hormoneCell neuronsCAMP levelsPresence of tetrodotoxinBag cell clustersAdenylate cyclase activator forskolinELH prohormoneCyclase activator forskolinElevation of cAMPMembrane-permeant cAMP analogAbdominal ganglionControl clustersPermeant cAMP analogueAction potentialsNeuroactive peptidesTreatment of cellsProtein synthesis inhibitor anisomycinActivator forskolinNeuronsProhormoneAfterdischargesCyclic AMPTetrodotoxinComparative peptide mapping
1989
Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons
Conn P, Strong J, Azhderian E, Nairn A, Greengard P, Kaczmarek L. Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons. Journal Of Neuroscience 1989, 9: 473-479. PMID: 2537389, PMCID: PMC6569795, DOI: 10.1523/jneurosci.09-02-00473.1989.Peer-Reviewed Original ResearchConceptsProtein kinase CBag cell neuronsVoltage-dependent calcium currentsCAMP-PKPhorbol esterKinase CCell neuronsAction potentialsCalcium currentInhibitor of PKCProtein kinase inhibitorsPhorbol ester-induced enhancementKinase inhibitor 1Protein kinase inhibitor 1Adenylate cyclase activator forskolinCyclase activator forskolinProtein inhibitorGranule movementVoltage-dependent currentsCell action potentialsCAMP analogEffect of forskolinActivator forskolinPhorbol ester-induced changesNeuronal excitabilityRegulation of ion channels in Aplysia neurons by autoactive peptides and second messengers.
Loechner K, Kaczmarek L. Regulation of ion channels in Aplysia neurons by autoactive peptides and second messengers. Society Of General Physiologists Series 1989, 44: 69-82. PMID: 2476858.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1987
Alpha bag cell peptide directly modulates the excitability of the neurons that release it
Kauer J, Fisher T, Kaczmarek L. Alpha bag cell peptide directly modulates the excitability of the neurons that release it. Journal Of Neuroscience 1987, 7: 3623-3632. PMID: 2824716, PMCID: PMC6569037, DOI: 10.1523/jneurosci.07-11-03623.1987.Peer-Reviewed Original ResearchConceptsAlpha-bag cell peptideBag cell neuronsAlpha-BCPCell neuronsBag cell peptidesPotassium currentCell peptidesVoltage-dependent potassium currentsCAMP levelsVoltage-dependent outward currentIntact abdominal gangliaBag cell clustersAdenylate cyclase activator forskolinAbility of forskolinCyclase activator forskolinLevels of cAMPVoltage-clamp experimentsElectrophysiological actionsIntracellular cAMP levelsImmunohistochemical stainingIntact gangliaAbdominal ganglionPhosphodiesterase inhibitorPharmacological elevationOutward currentsCyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons
Forscher P, Kaczmarek L, Buchanan J, Smith S. Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons. Journal Of Neuroscience 1987, 7: 3600-3611. PMID: 2824715, PMCID: PMC6569040, DOI: 10.1523/jneurosci.07-11-03600.1987.Peer-Reviewed Original Research
1986
Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclase
Strong J, Kaczmarek L. Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclase. Journal Of Neuroscience 1986, 6: 814-822. PMID: 2420948, PMCID: PMC6568473, DOI: 10.1523/jneurosci.06-03-00814.1986.Peer-Reviewed Original ResearchConceptsAction potentialsApplication of forskolinBag cell neuronsPotassium currentCell neuronsOutward currentsWhole-cell patch-clamp techniqueBag cell afterdischargePatch-clamp techniqueEffect of forskolinElevation of cAMPPeptidergic neuronsCalcium entryClamp techniqueAfterdischargesReproductive tractMsec depolarizationsAdenylate cyclasePrimary culturesHigh intracellular concentrationsNeuronsMin periodRepetitive activitySpike widthForskolin
1985
Peptidergic neurons of Aplysia lose their response to cyclic adenosine 3':5'-monophosphate during a prolonged refractory period
Kauer J, Kaczmarek L. Peptidergic neurons of Aplysia lose their response to cyclic adenosine 3':5'-monophosphate during a prolonged refractory period. Journal Of Neuroscience 1985, 5: 1339-1345. PMID: 2987438, PMCID: PMC6565048, DOI: 10.1523/jneurosci.05-05-01339.1985.Peer-Reviewed Original Research
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons
1982
Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia.
Strumwasser F, Kaczmarek L, Jennings K. Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia. The FASEB Journal 1982, 41: 2933-9. PMID: 6292000.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProtein phosphorylationCyclic AMPPotassium channelsBag cell neuronsEgg-laying hormoneMembrane channelsIntracellular modulationPhosphorylationPeptidergic bag cell neuronsCell neuronsExact identityPeptidergic neuronsImportant componentControl eggsElectrical afterdischargeNeuroactive peptidesAMPEggsCorrelated behaviorNeuronsAplysiaPeptidesProtein phosphorylation during afterdischarge in peptidergic neurons of Aplysia
Jennings K, Kaczmarek L, Hewick R, Dreyer W, Strumwasser F. Protein phosphorylation during afterdischarge in peptidergic neurons of Aplysia. Journal Of Neuroscience 1982, 2: 158-168. PMID: 6278103, PMCID: PMC6564306, DOI: 10.1523/jneurosci.02-02-00158.1982.Peer-Reviewed Original Research