1992
Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7
Loechner K, Mattessich-Arrandale J, Azhderian E, Kaczmarek L. Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7. Brain Research 1992, 581: 315-318. PMID: 1393536, DOI: 10.1016/0006-8993(92)90724-n.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAction PotentialsAnimalsAplysiaElectric StimulationGangliaIn Vitro TechniquesInvertebrate HormonesIsoquinolinesKineticsNeuronsPiperazinesProtein Kinase C
1991
Phosphorylation of membrane‐associated proteins by phorbol esters in isolated bag cell neurons of Aplysia
Azhderian E, Kaczmarek L. Phosphorylation of membrane‐associated proteins by phorbol esters in isolated bag cell neurons of Aplysia. Developmental Neurobiology 1991, 22: 105-115. PMID: 2030336, DOI: 10.1002/neu.480220202.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsAplysiaCell MembraneCells, CulturedElectrophoresis, Polyacrylamide GelEnzyme ActivationIsoquinolinesMembrane ProteinsNeuronsPhorbol EstersPhosphorylationPiperazinesProtein Kinase CTetradecanoylphorbol AcetateTrypsinConceptsProtein kinase CBag cell neuronsKinase CPlasma membrane-containing fractionsProtein kinase C inhibitor H7Membrane-associated proteinsPhorbol esterExtent of phosphorylationMembrane-containing fractionsCell neuronsMembrane proteinsProtein phosphorylationNew speciesPhosphorylation statePlasma membraneTetradecanoyl phorbol 13Inhibitor H7Inactive phorbol esterIntact cellsPhosphate incorporationProtein extractsPhosphoproteinExtracellular mediumPhosphorylationProtein
1989
Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons
Conn P, Strong J, Azhderian E, Nairn A, Greengard P, Kaczmarek L. Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons. Journal Of Neuroscience 1989, 9: 473-479. PMID: 2537389, PMCID: PMC6569795, DOI: 10.1523/jneurosci.09-02-00473.1989.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAction PotentialsAnimalsAplysiaCalciumColforsinCyclic AMPIsoquinolinesNeuronsOrganellesPhorbol EstersPhosphorylationPiperazinesProtein Kinase InhibitorsProtein KinasesProteinsConceptsProtein kinase CBag cell neuronsVoltage-dependent calcium currentsCAMP-PKPhorbol esterKinase CCell neuronsAction potentialsCalcium currentInhibitor of PKCProtein kinase inhibitorsPhorbol ester-induced enhancementKinase inhibitor 1Protein kinase inhibitor 1Adenylate cyclase activator forskolinCyclase activator forskolinProtein inhibitorGranule movementVoltage-dependent currentsCell action potentialsCAMP analogEffect of forskolinActivator forskolinPhorbol ester-induced changesNeuronal excitabilityInhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia
Conn P, Strong J, Kaczmarek L. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. Journal Of Neuroscience 1989, 9: 480-487. PMID: 2918372, PMCID: PMC6569798, DOI: 10.1523/jneurosci.09-02-00480.1989.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAbdomenAction PotentialsAnimalsAplysiaCalciumElectrophysiologyGangliaIsoquinolinesNeuronsNeuropeptidesPiperazinesProtein Kinase CSphingosineTetradecanoylphorbol Acetate