2020
Sparse Data–Driven Learning for Effective and Efficient Biomedical Image Segmentation
Onofrey JA, Staib LH, Huang X, Zhang F, Papademetris X, Metaxas D, Rueckert D, Duncan JS. Sparse Data–Driven Learning for Effective and Efficient Biomedical Image Segmentation. Annual Review Of Biomedical Engineering 2020, 22: 1-27. PMID: 32169002, PMCID: PMC9351438, DOI: 10.1146/annurev-bioeng-060418-052147.Peer-Reviewed Original Research
2017
Learning Non-rigid Deformations for Robust, Constrained Point-based Registration in Image-Guided MR-TRUS Prostate Intervention
Onofrey JA, Staib LH, Sarkar S, Venkataraman R, Nawaf CB, Sprenkle PC, Papademetris X. Learning Non-rigid Deformations for Robust, Constrained Point-based Registration in Image-Guided MR-TRUS Prostate Intervention. Medical Image Analysis 2017, 39: 29-43. PMID: 28431275, PMCID: PMC5514316, DOI: 10.1016/j.media.2017.04.001.Peer-Reviewed Original Research
2012
Volumetric Intraoperative Brain Deformation Compensation: Model Development and Phantom Validation
DeLorenzo C, Papademetris X, Staib LH, Vives KP, Spencer DD, Duncan JS. Volumetric Intraoperative Brain Deformation Compensation: Model Development and Phantom Validation. IEEE Transactions On Medical Imaging 2012, 31: 1607-1619. PMID: 22562728, PMCID: PMC3600363, DOI: 10.1109/tmi.2012.2197407.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiomechanical PhenomenaBrainGame TheoryHumansImaging, Three-DimensionalModels, NeurologicalPhantoms, ImagingReproducibility of ResultsSkullSurgery, Computer-AssistedConceptsLinear elastic modelSurface displacementsElastic modelBrain deformationVolumetric brain deformationMaterial parametersMaterial propertiesRealistic brain phantomDeformationBiomechanical modelIntraoperative brainModel accuracyLocalization errorPhantom validationAccurate surgical guidanceModel solutionsModel developmentInitial estimationDisplacementModel sensitivityQuantitative validationPhantom resultsPreoperative imagesSurgical guidancePreliminary applicationSimultaneous Nonrigid Registration, Segmentation, and Tumor Detection in MRI Guided Cervical Cancer Radiation Therapy
Lu C, Chelikani S, Jaffray DA, Milosevic MF, Staib LH, Duncan JS. Simultaneous Nonrigid Registration, Segmentation, and Tumor Detection in MRI Guided Cervical Cancer Radiation Therapy. IEEE Transactions On Medical Imaging 2012, 31: 1213-1227. PMID: 22328178, PMCID: PMC3889159, DOI: 10.1109/tmi.2012.2186976.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingPattern Recognition, AutomatedRadiotherapy, ConformalRadiotherapy, Image-GuidedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueUterine Cervical Neoplasms
2011
Fasciculography: Robust Prior-Free Real-Time Normalized Volumetric Neural Tract Parcellation
Ho P, Wang F, Papademetris X, Blumberg HP, Staib LH. Fasciculography: Robust Prior-Free Real-Time Normalized Volumetric Neural Tract Parcellation. IEEE Transactions On Medical Imaging 2011, 31: 217-230. PMID: 21914568, PMCID: PMC3640528, DOI: 10.1109/tmi.2011.2167629.Peer-Reviewed Original ResearchConceptsDiffusion tensor magnetic resonance imagesLess human interventionSearch spaceAbnormality detectionHuman interventionDiffusion tensor fieldsAbove problemsOrientation informationNonrigid registrationIncomplete reconstructionStreamline trackingTrackingOrientation errorsMagnetic resonance imagesImage artifactsTracking errorFiber trackingWhite matter fiber tractsLocal noiseTensor fieldsResonance imagesParcellation methodSame timeInitializationViable toolAn integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy
Lu C, Chelikani S, Papademetris X, Knisely JP, Milosevic MF, Chen Z, Jaffray DA, Staib LH, Duncan JS. An integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy. Medical Image Analysis 2011, 15: 772-785. PMID: 21646038, PMCID: PMC3164526, DOI: 10.1016/j.media.2011.05.010.Peer-Reviewed Original ResearchAlgorithmsBayes TheoremFemaleHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedUterine Cervical Neoplasms
2010
Refraction corrected transmission ultrasound computed tomography for application in breast imaging
Li S, Jackowski M, Dione DP, Varslot T, Staib LH, Mueller K. Refraction corrected transmission ultrasound computed tomography for application in breast imaging. Medical Physics 2010, 37: 2233-2246. PMID: 20527557, PMCID: PMC2874040, DOI: 10.1118/1.3360180.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsFeasibility StudiesFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalPhantoms, ImagingTime FactorsTomographyUltrasonography, MammaryIntegrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy
Lu C, Chelikani S, Chen Z, Papademetris X, Staib LH, Duncan JS. Integrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2010, 13: 53-60. PMID: 20879214, DOI: 10.1007/978-3-642-15705-9_7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedConceptsManual segmentationAutomatic segmentationImportant treatment parametersNonrigid registrationImage-guided radiotherapy systemReal patient dataNon-rigid registrationIntegrated SegmentationRegistration partRadiotherapy linear acceleratorSegmentationTreatment imagesImage qualityCone-beam CTTreatment parametersImagesPromising resultsPatient dataKey anatomical structuresLinear acceleratorRegistrationPrevious workRadiotherapy system
2009
Using Perturbation theory to reduce noise in diffusion tensor fields
Bansal R, Staib LH, Xu D, Laine AF, Liu J, Peterson BS. Using Perturbation theory to reduce noise in diffusion tensor fields. Medical Image Analysis 2009, 13: 580-597. PMID: 19540791, PMCID: PMC2782748, DOI: 10.1016/j.media.2009.05.001.Peer-Reviewed Original ResearchConceptsTensor fieldsDiffusion tensor fieldsPerturbation theoryMarkov random fieldPrior termDifferent spatial directionsRandom fieldsSymmetric tensorsRiemannian distanceSpatial directionsWhite matter fiber bundlesSmoothed fieldsLikelihood termEigenvaluesOriginal fieldEigenvectorsTensorReal-world datasetsDTI datasetsHomogeneous regionsTheoryLow signalNoiseNoise ratioFine structureFrom medical image computing to computer‐aided intervention: development of a research interface for image‐guided navigation
Papademetris X, DeLorenzo C, Flossmann S, Neff M, Vives KP, Spencer DD, Staib LH, Duncan JS. From medical image computing to computer‐aided intervention: development of a research interface for image‐guided navigation. International Journal Of Medical Robotics And Computer Assisted Surgery 2009, 5: 147-157. PMID: 19301361, PMCID: PMC2796181, DOI: 10.1002/rcs.241.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansImaging, Three-DimensionalNeurosurgical ProceduresRoboticsSoftwareSoftware DesignSurgery, Computer-AssistedConceptsResearch interfaceNavigation systemApplication programming interfaceDual computer systemComputer-aided interventionsSurgery navigation systemImage-guided navigation systemProgramming interfaceClient programNetwork interfacesMedical imagesImage-guided navigationResearch softwareReal timeViable solutionSoftwareImage analysis softwareTool positionVersatile linkAnalysis softwareImagesInterfaceNavigationSystemResearch techniquesVolumetric Shape Model for Oriented Tubular Structure from DTI Data
Ho HP, Papademetris X, Wang F, Blumberg HP, Staib LH. Volumetric Shape Model for Oriented Tubular Structure from DTI Data. Lecture Notes In Computer Science 2009, 12: 18-25. PMID: 20426091, PMCID: PMC2863144, DOI: 10.1007/978-3-642-04271-3_3.Peer-Reviewed Original ResearchConceptsBrain DTI dataMagnetic resonance diffusion tensor imagesContinuous modelStatistical methodsDiffusion tensor imagesSynthetic dataShape modelBoundary findingPoint correspondencesShape priorsDTI dataShape analysisVolumetric shapeTensor imagesWhole volumePriorsShape normalizationVolumetric shape modelsModelShapeOrientation information
2008
Calculation of the confidence intervals for transformation parameters in the registration of medical images
Bansal R, Staib LH, Laine AF, Xu D, Liu J, Posecion LF, Peterson BS. Calculation of the confidence intervals for transformation parameters in the registration of medical images. Medical Image Analysis 2008, 13: 215-233. PMID: 19138877, PMCID: PMC2891652, DOI: 10.1016/j.media.2008.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceConfidence IntervalsCorpus CallosumData Interpretation, StatisticalHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueConceptsSimilarity transformationMultivariate GaussianLeast squares estimationTransformation parametersMathematical frameworkRandom variablesPresence of noiseCovariance matrixLandmark pointsQuantifying errorsSimilarity parameterAmount of misregistrationInherent technological limitationsAmount of noiseGaussianCoordinatesInevitable errorsReal-world datasetsFunctional relationAmount of blurErrorParametersWorld datasetsNoiseConfidence intervalsNovel Interaction Techniques for Neurosurgical Planning and Stereotactic Navigation
Joshi A, Scheinost D, Vives KP, Spencer DD, Staib LH, Papademetris X. Novel Interaction Techniques for Neurosurgical Planning and Stereotactic Navigation. IEEE Transactions On Visualization And Computer Graphics 2008, 14: 1587-1594. PMID: 18989014, PMCID: PMC2633029, DOI: 10.1109/tvcg.2008.150.Peer-Reviewed Original ResearchEffects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotesUsing Perturbation Theory to Compute the Morphological Similarity of Diffusion Tensors
Bansal R, Staib L, Xu D, Laine A, Royal J, Peterson B. Using Perturbation Theory to Compute the Morphological Similarity of Diffusion Tensors. IEEE Transactions On Medical Imaging 2008, 27: 589-607. PMID: 18450533, PMCID: PMC2398733, DOI: 10.1109/tmi.2007.912391.Peer-Reviewed Original ResearchA Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy
Greene W, Chelikani S, Purushothaman K, Chen Z, Knisely J, Staib L, Papademetris X, Duncan J. A Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2008, 11: 780-788. PMID: 18979817, PMCID: PMC2790815, DOI: 10.1007/978-3-540-85988-8_93.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedConceptsTreatment planProstate image-guided radiotherapyOriginal treatment planRadiation dosageImage-guided radiotherapyTreatment daysRadiotherapy treatment plansCritical organsDifferent patientsPatient dataDifferent treatment daysBladderRectumProstateFemurBone motionCT imagesDosageReal patient dataPatientsRadiotherapy
2005
White matter tractography by anisotropic wavefront evolution and diffusion tensor imaging
Jackowski M, Kao CY, Qiu M, Constable RT, Staib LH. White matter tractography by anisotropic wavefront evolution and diffusion tensor imaging. Medical Image Analysis 2005, 9: 427-440. PMID: 16040268, PMCID: PMC2839167, DOI: 10.1016/j.media.2005.05.008.Peer-Reviewed Original ResearchROC-based assessments of 3D cortical surface-matching algorithms
Bansal R, Staib LH, Whiteman R, Wang YM, Peterson BS. ROC-based assessments of 3D cortical surface-matching algorithms. NeuroImage 2005, 24: 150-162. PMID: 15588606, DOI: 10.1016/j.neuroimage.2004.08.054.Peer-Reviewed Original ResearchCharacterizing Vascular Connectivity from microCT Images
Jackowski M, Papademetris X, Dobrucki LW, Sinusas AJ, Staib LH. Characterizing Vascular Connectivity from microCT Images. Lecture Notes In Computer Science 2005, 8: 701-708. PMID: 16686021, DOI: 10.1007/11566489_86.Peer-Reviewed Original ResearchArticulated Rigid Registration for Serial Lower-Limb Mouse Imaging
Papademetris X, Dione DP, Dobrucki LW, Staib LH, Sinusas AJ. Articulated Rigid Registration for Serial Lower-Limb Mouse Imaging. Lecture Notes In Computer Science 2005, 8: 919-926. PMID: 16686048, DOI: 10.1007/11566489_113.Peer-Reviewed Original Research