2021
Gerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingDrug Resistant EpilepsyElectric StimulationFemaleGerstmann SyndromeHumans
2018
Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram
Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.Peer-Reviewed Original ResearchConceptsAED taperYale-New Haven HospitalAdult epilepsy patientsSeizure forecasting algorithmsElectrode contact pairsSeizure onset areaSeizure susceptibilityClinical recordsDrug taperElectrophysiological changesEpilepsy patientsIntracranial electroencephalographic dataMagnitude-squared coherenceModulatory activitySeizuresPatientsOnset areaPreseizurePostseizureProgressive desynchronizationIntracranial electroencephalogramDaysIctogenesisEffect of timeHospitalPresurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICarePresurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning
Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.Peer-Reviewed Original ResearchConceptsLanguage functional MRISurgical marginsFunctional MRIPatient outcomesClinical practiceEpilepsy surgical planningEpilepsy surgical programsCurrent clinical practiceDirect brain stimulationEpilepsy surgeryStimulation mappingBrain stimulationClinical teamLanguage lateralizationSurgical programsSurgical planningLanguage-critical areasFMRI findingsFMRI paradigmUnexpected preservationFurther validationLanguage declineAdultsOutcomesChildren
2017
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception
Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.Peer-Reviewed Original ResearchConceptsCerebral cortexVisual cortexHuman cerebral cortexDirect electrical recordingHz gamma powerDefault mode networkConscious perceptionNeuronal activityAssociation cortexBrain disordersIntracranial electrodesCortexMonophasic wavesMode networkCortex networkGamma powerGamma activationVisual thresholdFirst secondElectrical recordingsStimulus processingInitial activationStimuliActivationFindingsPresurgical language fMRI: Mapping of six critical regions
Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.Peer-Reviewed Original ResearchConceptsLanguage lateralityWernicke's areaLanguage regionsBasal temporal language areaHum Brain MappTemporal language areaTumor patientsLanguage cortexIndependent cliniciansClinical fMRIExperienced cliniciansCliniciansLanguage mappingLanguage-critical areasSpeech areasAngular gyrusExner's areaLateralityFMRI taskBroca's areaBlind reviewNeurosurgical planningLanguage areasClinical neuropsychologistsFMRI dataBrain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas
Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingCerebral CortexDeep Brain StimulationDrug Resistant EpilepsyElectric Stimulation TherapyElectrodes, ImplantedElectroencephalographyEpilepsies, PartialEpilepsy, Complex PartialEpilepsy, Partial, MotorEpilepsy, Tonic-ClonicFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedNeocortexYoung AdultConceptsSeizure-free periodSeizure reductionNeocortical onsetSeizure onsetNeocortical originIntractable partial-onset seizuresMedian percent seizure reductionBrain-responsive neurostimulationChronic neurologic deficitsPercent seizure reductionPrior epilepsy surgeryPartial-onset seizuresPercent of patientsProspective clinical trialsNormal MRI findingsVagus nerve stimulationEffective treatment optionEloquent cortical areasRate of infectionMagnetic resonance imagingPreimplantation baselineMRI lesionsAdverse eventsNeurologic deficitsPerioperative hemorrhage
2016
Regional and network relationship in the intracranial EEG second spectrum
Joshi RB, Gaspard N, Goncharova II, Duckrow RB, Duncan D, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Regional and network relationship in the intracranial EEG second spectrum. Clinical Neurophysiology 2016, 127: 3485-3491. PMID: 27692590, DOI: 10.1016/j.clinph.2016.09.003.Peer-Reviewed Original ResearchProgressive change in sleep over multiple nights of intracranial EEG monitoring
Joshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology 2016, 127: 2302-2307. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingElectroencephalographyEpilepsyFemaleHumansMaleMiddle AgedSleepYoung Adult
2014
The spatial and signal characteristics of physiologic high frequency oscillations
Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.Peer-Reviewed Original ResearchConceptsPhysiologic high-frequency oscillationsSeizure onsetEpileptic networkNon-rapid eye movement sleepComprehensive Epilepsy CenterMesial temporal structuresEye movement sleepHighest HFO ratesHigh-frequency oscillationsFirst seizureInvasive evaluationEpilepsy centersIntracranial evaluationMovement sleepPerirolandic regionEpileptiform dischargesParietooccipital regionOccipital lobeEpileptic sitesPatientsNonepileptic regionsPhysiologic eventsFast ripplesHFO ratesLonger durationProceedings of the Fifth International Workshop on Advances in Electrocorticography
Ritaccio A, Brunner P, Gunduz A, Hermes D, Hirsch LJ, Jacobs J, Kamada K, Kastner S, Knight RT, Lesser RP, Miller K, Sejnowski T, Worrell G, Schalk G. Proceedings of the Fifth International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2014, 41: 183-192. PMID: 25461213, PMCID: PMC4268064, DOI: 10.1016/j.yebeh.2014.09.015.Peer-Reviewed Original Research
2013
Proceedings of the Fourth International Workshop on Advances in Electrocorticography
Ritaccio A, Brunner P, Crone NE, Gunduz A, Hirsch LJ, Kanwisher N, Litt B, Miller K, Moran D, Parvizi J, Ramsey N, Richner TJ, Tandon N, Williams J, Schalk G. Proceedings of the Fourth International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2013, 29: 259-268. PMID: 24034899, PMCID: PMC3896917, DOI: 10.1016/j.yebeh.2013.08.012.Peer-Reviewed Original ResearchIntracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day
Goncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology 2013, 124: 2119-2128. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.Peer-Reviewed Original ResearchSeizure localization using three-dimensional surface projections of intracranial EEG power
Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-626. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.Peer-Reviewed Original ResearchConceptsEpilepsy surgerySeizure localizationGood surgical outcomeEEG powerIntractable epilepsy patientsAgreement rateNormal brain functionOverall agreement ratePoor outcomeSurgical outcomesIntractable epilepsyIcEEG recordingsSeizure onsetSublobar localizationEpilepsy patientsIndependent reviewersClinical informationIcEEG dataPatientsBrain functionSurgeryImproved diagnostic methodIntracranial EEGDiagnostic methodsOutcomesIntracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2011
Imaging findings in encephalocraniocutaneous lipomatosis
Svoronos A, Hirsch LJ, Khandji AG. Imaging findings in encephalocraniocutaneous lipomatosis. Neurology 2011, 77: 694. PMID: 21844526, DOI: 10.1212/wnl.0b013e3182299fa9.Peer-Reviewed Original Research
2009
Intracortical electroencephalography in acute brain injury
Waziri A, Claassen J, Stuart RM, Arif H, Schmidt JM, Mayer SA, Badjatia N, Kull LL, Connolly ES, Emerson RG, Hirsch LJ. Intracortical electroencephalography in acute brain injury. Annals Of Neurology 2009, 66: 366-377. PMID: 19798724, DOI: 10.1002/ana.21721.Peer-Reviewed Original ResearchConceptsSecondary neurological complicationsElectrographic seizuresIctal activityNeurological complicationsScalp electroencephalographyNeurological injuryBrain injuryIntracortical EEGIntensive care unit settingSecondary neurological injurySecondary neuronal injuryAcute brain injuryIll neurological patientsIntracortical electroencephalographyClinical deteriorationNeuronal injuryInvasive neuromonitoringUnderwent implantationNeuromonitoring modalitiesBedside placementIctal dischargesRhythmic deltaUnit settingAcute changesContinuous electroencephalographyClinical use of ictal SPECT in secondarily generalized tonic–clonic seizures
Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Paige AL, Zubal IG, Spencer SS, Blumenfeld H. Clinical use of ictal SPECT in secondarily generalized tonic–clonic seizures. Brain 2009, 132: 2102-2113. PMID: 19339251, PMCID: PMC2714057, DOI: 10.1093/brain/awp027.Peer-Reviewed Original ResearchConceptsCerebral blood flow increasesBlood flow increasesGeneralized tonic-clonic seizuresIctal SPECTTonic-clonic seizuresPartial seizuresPost-ictal periodSeizure onsetGeneralized seizuresSecondary generalizationCerebral blood flow decreasesRegional cerebral blood flow increasesPropagation of seizuresBlood flow decreaseCerebral blood flowEpilepsy surgery evaluationUseful clinical toolSingle photon emissionFlow increasesSeizure localizationSurgery evaluationBlood flowSeizuresClinical toolClinical use
2004
Inadequacy of Standard Screen Resolution for Localization of Seizures Recorded from Intracranial Electrodes
Schevon CA, Thompson T, Hirsch LJ, Emerson RG. Inadequacy of Standard Screen Resolution for Localization of Seizures Recorded from Intracranial Electrodes. Epilepsia 2004, 45: 1453-1458. PMID: 15509247, DOI: 10.1111/j.0013-9580.2004.67603.x.Peer-Reviewed Original ResearchContinuous EEG Monitoring in the Intensive Care Unit
Hirsch LJ, Kull LL. Continuous EEG Monitoring in the Intensive Care Unit. The Neurodiagnostic Journal 2004, 44: 137-158. PMID: 15521467, DOI: 10.1080/1086508x.2004.11079478.Peer-Reviewed Original ResearchConceptsContinuous EEG monitoringIntensive care unitCare unitEEG monitoringPrevention of strokeQuantitative EEG analysisCEEG interpretationCerebral ischemiaIll patientsNonconvulsive seizuresElectrographic seizuresAcute ischemiaClinical correlatesMental statusBrain injuryAlerting stimuliBrain functionEEG patternsEarly detectionEEG technologistsReversible stageIschemiaPatientsSeizuresTechnical difficulties