2023
Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociation
2020
Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays
Gao D, Pollitt K, Mulholland J, Russell A, Weber R. Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays. Atmospheric Chemistry And Physics 2020, 20: 5197-5210. DOI: 10.5194/acp-20-5197-2020.Peer-Reviewed Original ResearchWater-soluble CuOP assaysMetal ionsOxidative potentialMetal-metal interactionsChemical componentsHumic-like substancesAscorbic acidSynthetic respiratory tract lining fluidDepletion of dithiothreitolMetal speciesOrganic compoundsPM2.5 oxidative potentialBrown carbonMajor chemical componentsOPGSHIonsRespiratory tract lining fluidAcellular assaysParticle composition dataElemental carbonCuCarbonOPAAOPDTT