2023
Is Adherence to Guidelines Helpful? Endoscopic Hemostasis of Bleeding Peptic Ulcers with Adherent Clots
Hung K. Is Adherence to Guidelines Helpful? Endoscopic Hemostasis of Bleeding Peptic Ulcers with Adherent Clots. Digestive Diseases And Sciences 2023, 68: 3843-3845. PMID: 37634183, DOI: 10.1007/s10620-023-08082-1.Commentaries, Editorials and Letters
2022
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding
Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsGastrointestinal bleedingPrimary preventionCardiovascular eventsRisk of MACEYale-New Haven HospitalPrimary cardiovascular preventionAdverse cardiovascular eventsKaplan-Meier curvesLong-term outcomesRisk-benefit ratioLog-rank testAspirin 81Hospitalised patientsPrimary endpointSecondary endpointsCardiovascular preventionSubsequent hospitalisationMedian ageDeprescriptionHigh riskAspirinHospitalisationPatientsPreventionAn Uncommon Cause of Coffee Ground Emesis in a Young Woman With Remote Roux-en-Y Gastric Bypass
Mezzacappa C, Hughes ML, Hung KW. An Uncommon Cause of Coffee Ground Emesis in a Young Woman With Remote Roux-en-Y Gastric Bypass. Gastroenterology 2022, 163: e16-e17. PMID: 35490784, DOI: 10.1053/j.gastro.2022.04.032.Peer-Reviewed Case Reports and Technical NotesIncreased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic
Ilagan-Ying YC, Almeida MN, Kahler-Quesada A, Ying L, Hughes ML, Do A, Hung KW. Increased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic. Digestive Diseases And Sciences 2022, 67: 5053-5062. PMID: 35182250, PMCID: PMC8857390, DOI: 10.1007/s10620-022-07414-x.Peer-Reviewed Original ResearchConceptsInpatient endoscopyCare centerEndoscopic proceduresIntensive care unit admissionAcademic tertiary care centerCare unit admissionProportion of patientsTertiary care centerCoronavirus disease 2019 (COVID-19) pandemicHigher mortality riskDisease 2019 pandemicEarly COVID-19 pandemicICU admissionUnit admissionPatient demographicsUrgent indicationsBlood transfusionFirst waveHigher proportionPatient reluctanceMale genderUrgent proceduresProcedural characteristicsHospital careMost healthcare systems
2021
Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists
Hughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImmune Checkpoint Inhibitor–associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies
Tran AN, Wang M, Hundt M, Chugh R, Ohm J, Grimshaw A, Ciarleglio M, Hung KW, Proctor DD, Price CC, Laine L, Al-Bawardy B. Immune Checkpoint Inhibitor–associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies. Journal Of Immunotherapy 2021, 44: 325-334. PMID: 34380976, DOI: 10.1097/cji.0000000000000383.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsDiarrhea/colitisICI therapyCheckpoint inhibitorsObservational studyAnti-programmed cell death-1/Outcomes of ICISystematic reviewCell death-1/Permanent ICI discontinuationReal-world incidenceRemission of diarrheaRecurrence of symptomsDeath-1/Treatment of diarrheaRandom-effects modelICI discontinuationAdvanced malignanciesAppropriate patientsPrimary outcomeOverall incidenceAntigen-4Early treatmentColitisHigh risk
2020
The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study
Ramos GP, Dimopoulos C, McDonald NM, Janssens LP, Hung KW, Proctor D, Ruggiero E, Kane S, Bruining DH, Faubion WA, Raffals LE, Loftus EV, Al-Bawardy B. The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study. Inflammatory Bowel Diseases 2020, 27: 1270-1276. PMID: 33165569, DOI: 10.1093/ibd/izaa293.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseExtraintestinal manifestationsPeripheral arthritisBowel diseaseDose of vedolizumabPrevious biologic useMulticenter retrospective studyCurrent medical therapyTerms of ageConcurrent immunosuppressantsCorticosteroid therapyVDZ treatmentIBD subtypesBiologic useSecondary outcomesMedical therapyPrimary outcomeClinical outcomesMulticenter studyRetrospective studyVedolizumabPatientsCommon typeDiscontinuationArthritis
2019
Minor Hematochezia Decreases Use of Venous Thromboembolism Prophylaxis in Patients with Inflammatory Bowel Disease
Faye AS, Hung KW, Cheng K, Blackett JW, Mckenney AS, Pont AR, Li J, Lawlor G, Lebwohl B, Freedberg DE. Minor Hematochezia Decreases Use of Venous Thromboembolism Prophylaxis in Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2019, 26: 1394-1400. PMID: 31689354, PMCID: PMC7534414, DOI: 10.1093/ibd/izz269.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseVTE prophylaxisProphylaxis ratesVenous thromboembolismBowel diseaseVTE prophylaxis ratesVTE prophylaxis useBlood transfusion rateRetrospective cohort studyVenous thromboembolism prophylaxisStrong independent predictorExposure of interestChronic bleedingProphylaxis useThromboembolism prophylaxisTransfusion rateCohort studyHospitalized patientsIndependent predictorsPrimary outcomeHemoglobin levelsMedical recordsHematocheziaProphylaxisPatientsFactors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer Disease
Hung KW, Knotts RM, Faye AS, Pont AR, Lebwohl B, Abrams JA, Freedberg DE. Factors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer Disease. Clinical Gastroenterology And Hepatology 2019, 18: 1091-1098.e1. PMID: 31352090, DOI: 10.1016/j.cgh.2019.07.037.Peer-Reviewed Original ResearchConceptsPeptic ulcer diseaseIntensive care unitH pyloriUlcer diseaseGastrointestinal bleedingDuodenal ulcerPylori infectionKaplan-Meier analysisH pylori infectionHelicobacter pylori infectionYear of admissionHelicobacter pylori testingElectronic medical recordsEvidence of testsIndex endoscopyCoagulation statusComposite outcomeEndoscopic factorsBlood lossHospital admissionCare unitRetrospective studyMedical recordsMultivariable modelUlcer severity