Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV
Abi N, Young A, Tiwari P, Chen J, Liu C, Hui Q, So-Armah K, Freiberg M, Justice A, Xu K, Gwinn M, Marconi V, Sun Y. Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV. Epigenomes 2024, 8: 46. DOI: 10.3390/epigenomes8040046.Peer-Reviewed Original ResearchMethylation risk scoreBody mass indexReduce cardiometabolic disease riskBody mass index associationsMass indexBody mass index varianceRisk of type 2 diabetesVeterans Aging Cohort StudyEpigenome-wide association studiesAnalysis of body mass indexCardiometabolic disease riskAntiretroviral therapyAging Cohort StudyNon-HIV individualsObesity-related risksEpigenome-wide significant CpG-sitesMale PWHLinear mixed modelsTargeted interventionsType 2 diabetesCohort studyDisease riskRisk scorePWHAssociation studiesChildhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 47: 913-926. PMID: 38762606, PMCID: PMC11365810, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass index