2018
Morphogenesis and Compartmentalization of the Intestinal Crypt
Sumigray KD, Terwilliger M, Lechler T. Morphogenesis and Compartmentalization of the Intestinal Crypt. Developmental Cell 2018, 45: 183-197.e5. PMID: 29689194, PMCID: PMC5987226, DOI: 10.1016/j.devcel.2018.03.024.Peer-Reviewed Original ResearchConceptsRac1 null miceAdult mammalian intestineCell shape changesProgenitor cellsStem cell nicheGene networksCrypt morphogenesisCrypt progenitor cellsEssential regulatorMammalian intestineCell nicheGenetic analysisUnexpected roleApical constrictionNiche formationHemidesmosomal adhesionCrypt developmentTissue architectureMouse cryptsMorphogenesisAbsorptive villiNull miceIntestinal cryptsQuantitative morphometricsShape changes
2011
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis
Sumigray KD, Chen H, Lechler T. Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. Journal Of Cell Biology 2011, 194: 631-642. PMID: 21844209, PMCID: PMC3160577, DOI: 10.1083/jcb.201104009.Peer-Reviewed Original ResearchMeSH Keywords1-Alkyl-2-acetylglycerophosphocholine EsteraseAlpha CateninAnimalsCarrier ProteinsCell DifferentiationCell ProliferationCells, CulturedDesmoplakinsDesmosomesEpidermisFluorescent Antibody TechniqueKeratinocytesMiceMice, KnockoutMicrotubule-Associated ProteinsMicrotubulesPermeabilityProtein TransportRecombinant Fusion ProteinsTransfectionConceptsDesmosomal protein desmoplakinCortical microtubule organizationCentrosomal proteinsMicrotubule organizationCell cortexMicrotubule reorganizationCell-cell adhesion structuresPenetrant perinatal lethalityDramatic defectsDesmosome stabilityCytoskeletal networkAdhesion structuresPerinatal lethalityUnexpected roleSingle isoformDesmosomal componentsBarrier activityCell typesDesmosomal proteinsEpidermal differentiationKeratin filamentsIntermediate filamentsProteinLIS1Specific subset