2022
Host gene effects on gut microbiota in type 1 diabetes
Guo K, Huang J, Zhou Z. Host gene effects on gut microbiota in type 1 diabetes. Biochemical Society Transactions 2022, 50: 1133-1142. PMID: 35521897, PMCID: PMC9246325, DOI: 10.1042/bst20220004.Peer-Reviewed Original ResearchConceptsType 1 diabetesMicrobiome compositionPancreatic β-cell lossT1D susceptibility genesT1D developmentHost genesImmunity genesGenetic lociGut microbiotaGene effectsModel of T1DNon-obese diabetic (NOD) miceOrgan-specific autoimmune diseasesΒ-cell lossGenesSusceptibility genesGenetic backgroundGenetic variantsMicrobiota interactionsRisk of T1DPancreatic islet autoantigensGut microbiota diversityGut microbiome compositionIslet autoimmunityT1D progression
2018
Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes
Huang J, Xiao Y, Zheng P, Zhou W, Wang Y, Huang G, Xu A, Zhou Z. Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes/Metabolism Research And Reviews 2018, 35: e3064. PMID: 30123986, DOI: 10.1002/dmrr.3064.Peer-Reviewed Original ResearchConceptsNeutrophil countType 1 diabetesT1D patientsNeutrophil numbersPhagocytosis rateTitres of autoantibodiesΒ-cell antigensΒ-cell autoimmunityChemokine receptor expressionType 2 diabetesMigration of neutrophilsLADA patientsPositive autoantibodiesAutoimmune diabetesChemokine levelsCD62L expressionT2D patientsClinical parametersNeutrophil migrationHealthy controlsReceptor expressionAnimal modelsDiabetesPatientsDifferent subtypes