2024
Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats
Martínez-Magaña J, Genis-Mendoza A, Gallegos-Silva I, López-Narváez M, Juárez-Rojop I, Diaz-Zagoya J, Tovilla-Zárate C, González-Castro T, Nicolini H, Solis-Medina A. Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats. Nutrients 2024, 16: 490. PMID: 38398814, PMCID: PMC10892058, DOI: 10.3390/nu16040490.Peer-Reviewed Original ResearchConceptsMood-related behaviorsConsumption of aspartameHippocampus of ratsAnxiety-like behaviorDepressive-like behaviorChronic consumptionSerotoninergic genesDefensive buryingNeurobiological alterationsSerotonin genesBrain areasNeurodevelopmental stagesBrain expressionMale Wistar ratsReduced weight gainDifferential effectsHippocampusDifferential alterationsWistar ratsBrainSystem genesRatsBody mass index controlWeight gainAlteration of expression
2018
Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats
Solis-Medina A, Martínez-Magaña JJ, Quintanar-Jurado V, Gallegos-Silva I, Juárez-Rojop IE, Tovilla-Zárate CA, Díaz-Zagoya JC, Hernández-Díaz Y, González-Castro TB, López-Narváez ML, Genis-Mendoza AD, Nicolini H. Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats. Metabolic Brain Disease 2018, 33: 2031-2038. PMID: 30264280, DOI: 10.1007/s11011-018-0310-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartameBrainCell SurvivalGliosisMaleNeuronsRatsRats, WistarSweetening AgentsThiazinesConceptsMale Wistar ratsNeuronal specific enolaseNeuronal viabilityWistar ratsPrefrontal cortexChronic consumptionNeural viabilityConsumption of aspartameHematoxylin-eosin stainingConsumption of sweetenersHistological alterationsAstrogliosisImmunohistochemical techniquesBrain areasControl groupNeural modificationsNeuronal morphologyPyknotic nucleiHistological analysisHippocampusAmygdalaRatsCortexEarly ageEarly consumption