Featured Publications
Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence
Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence. Biomedicines 2022, 10: 1107. PMID: 35625844, PMCID: PMC9138536, DOI: 10.3390/biomedicines10051107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPosttraumatic stress disorderPeripheral immune systemImmune systemInflammatory systemTrauma exposureStress disorderPeripheral immune dysregulationToll-like receptorsLifetime trauma exposurePotential novel drug targetsEtiology of PTSDImmune dysregulationInflammatory dysregulationHPA axisNovel drug targetsImmunological responseInflammatory signalingGeneral populationAnimal modelsIntegrative multi-omics approachPTSD treatmentMultifactorial disorderBrain tissueHallmark featureDysregulation
2023
Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review
Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.Peer-Reviewed Original ResearchG protein-coupled receptorsPosttraumatic stress disorderEpigenomic findingsEpigenomic studiesEpigenomic profilesTranscriptomic modificationsEpigenetic studiesBrain transcriptomicsBiological pathwaysComplex multifactorial disorderGenesBrain tissueGene-environment interplayStress disorderSpeciesHuman postmortem samplesChemical synaptic transmissionSystematic literature searchEnvironmental factorsCurrent knowledge gapsPotential roleOrexin pathwayPathwayBrain alterationsPeripheral tissues