2024
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylation
2019
Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies
González‐Castro T, Tovilla‐Zárate C, Genis‐Mendoza A, Juárez‐Rojop I, Nicolini H, López‐Narváez M, Martínez‐Magaña J. Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 320-329. PMID: 31045331, DOI: 10.1002/ajmg.b.32731.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesBiological process gene ontologyGene OntologyProtein localizationPositive regulationKEGG pathwaysEnrichment analysisGenomes (KEGG) biological pathwaysHeterotypic cell-cell adhesionCell-cell adhesionGlucose importKyoto EncyclopediaGO analysisCardiomyopathy pathwaysGWAS studiesBiological pathwaysAssociation studiesGenesGenetic contributorsMultiple large-scale studiesEndopeptidase activityInsulin stimulusPathwayRegulationMuscle cell contraction