2023
Decline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”
Rudisill K, Ratnasamy P, Maloy G, Grauer J. Decline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 938-944. PMID: 37332184, DOI: 10.5435/jaaos-d-22-01029.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexSurgeon specialtySpinal fusionComorbidity indexSmoking statusGold standardIliac crest autograftPatient ageIndependent predictorsPatient factorsNonsurgical factorsCrest autograftSpine surgeryBone graftingSpine fusionIliac crestBone graftAutograftYounger ageSurgeryInsurance factorsSpinal boneCommon procedureInsurance plansAge
2014
Short-Term Adverse Events, Length of Stay, and Readmission After Iliac Crest Bone Graft for Spinal Fusion
Gruskay JA, Basques BA, Bohl DD, Webb ML, Grauer JN. Short-Term Adverse Events, Length of Stay, and Readmission After Iliac Crest Bone Graft for Spinal Fusion. Spine 2014, 39: 1718-1724. PMID: 24979140, DOI: 10.1097/brs.0000000000000476.Peer-Reviewed Original ResearchConceptsIliac crest bone graftLength of stayPostoperative blood transfusionAdverse eventsCrest bone graftReadmission ratesBlood transfusionOperative timeSpinal fusionMultivariate analysisICBG cohortBone graftRetrospective cohort studyShort-term morbidityTerm adverse eventsShort-term outcomesBone graft harvestBivariate logistic regressionDonor site morbidityDatabase cohortCohort studySurgical dataSurgical timeGraft harvestBACKGROUND DATA
2012
The Efficacies of 2 Ceramic Bone Graft Extenders for Promoting Spinal Fusion in a Rabbit Bone Paucity Model
Miller CP, Jegede K, Essig D, Garg H, Bible JE, Biswas D, Whang PG, Grauer JN. The Efficacies of 2 Ceramic Bone Graft Extenders for Promoting Spinal Fusion in a Rabbit Bone Paucity Model. Spine 2012, 37: 642-647. PMID: 21857402, DOI: 10.1097/brs.0b013e31822e604e.Peer-Reviewed Original Research
2011
A novel technique for preparing an allograft fibula for use as a transsacral graft as treatment for high-grade spondylolisthesis.
Milewski MD, Whang PG, Grauer JN. A novel technique for preparing an allograft fibula for use as a transsacral graft as treatment for high-grade spondylolisthesis. The American Journal Of Orthopedics 2011, 40: 130-3, 138. PMID: 21738906.Peer-Reviewed Original ResearchConceptsAnterior cruciate ligamentInstrumented posterolateral fusionFibular allograftPosterolateral fusionHigh-grade spondylolisthesisAllograft fibulaIndex surgerySixth patientAdverse eventsIntraoperative complicationsProminent hardwareCruciate ligamentAllograftsPatientsS1 segmentPosterior implantationDeformityReamerL5ComplicationsSpondylolisthesisSurgeryGraftIleumYears
2010
Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion.
Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. The American Journal Of Orthopedics 2010, 39: 531-8. PMID: 21623419.Peer-Reviewed Original ResearchConceptsFusion rateGraft alternativesPosterolateral lumbar spinal fusionLumbar spinal fusionRhBMP-2Spine fusion modelDose-response curveEctopic bone formation modelBone graft alternativesStudy ratsLumbar fusionRat modelSpinal fusionSpine fusionB graftsRecombinant human bone morphogenetic protein-2Manual palpationHuman bone morphogenetic protein-2Bone matrix productsSignificant differencesProtein 2DBM carrierBone matrixAutograftBone morphogenetic protein-2
2008
Silicates and bone fusion.
Waked W, Grauer J. Silicates and bone fusion. Orthopedics 2008, 31: 591-7. PMID: 18661882, DOI: 10.3928/01477447-20080601-34.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2007
rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model
Lawrence JP, Waked W, Gillon TJ, White AP, Spock CR, Biswas D, Rosenberger P, Troiano N, Albert TJ, Grauer JN. rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model. Spine 2007, 32: 1206-1213. PMID: 17495777, DOI: 10.1097/brs.0b013e318054721e.Peer-Reviewed Original ResearchAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone SubstitutesBone TransplantationChemistry, PharmaceuticalDisease Models, AnimalDrug CarriersFemaleHumansIliumLumbar VertebraeNicotineOsseointegrationPseudarthrosisRabbitsRecombinant ProteinsSpinal FusionTime FactorsTomography, X-Ray ComputedTransforming Growth Factor betaTransplantation, Autologous
2006
Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model
Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN. Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model. Spine 2006, 31: 2180-2188. PMID: 16946651, DOI: 10.1097/01.brs.0000232823.82106.0a.Peer-Reviewed Original ResearchConceptsRecombinant human growthDifferentiation factor 5Fusion ratePosterolateral lumbar spine fusionPosterolateral lumbar fusionIliac crest autograftLumbar spine fusionNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsRabbit fusion modelWhite rabbit modelIntertransverse process fusionBone graft alternativesCrest autograftLumbar fusionBACKGROUND DATAHistologic differencesPreclinical studiesSpine fusionTreatment groupsFactor 5Histologic analysisBone graftFusion mass
2005
Animal models for spinal fusion
Drespe IH, Polzhofer GK, Turner AS, Grauer JN. Animal models for spinal fusion. The Spine Journal 2005, 5: s209-s216. PMID: 16291115, DOI: 10.1016/j.spinee.2005.02.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe evolution of allograft bone for spinal applications.
Grauer JN, Beiner JM, Kwon B, Vaccaro AR. The evolution of allograft bone for spinal applications. Orthopedics 2005, 28: 573-7; quiz 578-9. PMID: 16138470, DOI: 10.3928/0147-7447-20050601-13.Peer-Reviewed Original Research
2004
Posterolateral lumbar fusions in athymic rats: characterization of a model
Grauer JN, Bomback DA, Lugo R, Troiano NW, Patel TC, Friedlaender GE. Posterolateral lumbar fusions in athymic rats: characterization of a model. The Spine Journal 2004, 4: 281-286. PMID: 15125850, DOI: 10.1016/j.spinee.2003.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone TransplantationFemaleLumbar VertebraeModels, AnimalPalpationRadiographyRatsRats, NudeSpinal FusionConceptsPosterolateral lumbar fusion modelAthymic ratsManual palpationPosterolateral lumbar fusionL4-L5 levelSmall animal modelsPotential inflammatory responseLumbar fusionInflammatory responseSpinal fusionHistology resultsAutograft fusionAnimal modelsFusion rateOsteoinductive productsRatsIntertransverse fusionPalpationSurvival surgeryGraftWeeksComparison of FusionSpontaneous fusionLimited utilityXenogenic proteins
2003
Bone Graft Alternatives for Spinal Fusion
Grauer JN, Beiner JM, Kwon BK, Vaccaro AR. Bone Graft Alternatives for Spinal Fusion. BioDrugs 2003, 17: 391-394. PMID: 14614762, DOI: 10.2165/00063030-200317060-00002.ChaptersPostoperative wound infections of the spine.
Beiner JM, Grauer J, Kwon BK, Vaccaro AR. Postoperative wound infections of the spine. Neurosurgical FOCUS 2003, 15: e14. PMID: 15347232, DOI: 10.3171/foc.2003.15.3.14.BooksMeSH KeywordsAnti-Bacterial AgentsAntibiotic ProphylaxisBlood SedimentationBone TransplantationCombined Modality TherapyComorbidityC-Reactive ProteinDebridementDiagnostic ImagingDisease SusceptibilityDiskectomyDrug Therapy, CombinationEquipment ContaminationHumansInternal FixatorsMalnutritionNutritional SupportReoperationRisk FactorsSpineSurgical Wound InfectionTherapeutic IrrigationConceptsRate of infectionLumbar surgeryWound infectionNutritional statusPostoperative spinal wound infectionsAntibiotic prophylactic therapySpinal wound infectionsPostoperative wound infectionUncomplicated postoperative courseErythrocyte sedimentation rateC-reactive proteinPossibility of infectionMajority of casesSubfascial layerProphylactic therapyAggressive treatmentPostoperative coursePatient factorsWound swellingClinical symptomsSuperficial infectionRisk factorsBone graftInfectionComplete eradication
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusionEvaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute