2024
Improved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization
Seddio A, Wilhelm C, Gouzoulis M, Islam W, Vasudevan R, Halperin S, Rubin L, Medvecky M, Donohue K, Grauer J. Improved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization. JSES International 2024 DOI: 10.1016/j.jseint.2024.10.006.Peer-Reviewed Original ResearchTotal shoulder arthroplastyBody mass indexT2DM patientsElixhauser Comorbidity IndexMultivariate analysisOdds of surgical site infectionUrinary tract infectionSurgical site infectionAcute kidney injuryType II diabetes mellitusII diabetes mellitusTract infectionsSite infectionClinical benefitPreoperative optimizationCardiac eventsKidney injuryVenous thromboembolismMetformin useAdverse eventsManagement of type II diabetes mellitusMass indexDiabetes mellitusType II diabetesAdverse outcomesLower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair
Seddio A, Moran J, Gouzoulis M, Garbis N, Salazar D, Grauer J, Jimenez A. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024 PMID: 39490542, DOI: 10.1016/j.arthro.2024.09.057.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairT2DM patientsRotator cuff retearRotator cuff repairElixhauser Comorbidity IndexAdverse eventsLow risk of postoperative complicationsOdds ratioRisk of postoperative complicationsKaplan-Meier survival analysisUrinary tract infectionSurgical-site infectionCuff repairLog-rank testRetrospective comparative studyAcute kidney injuryMinor adverse eventsType II diabetes mellitusAssociated with decreased oddsMultivariate logistic regressionArthroscopic shoulder proceduresII diabetes mellitusAdministrative billing codesPostoperative complicationsTract infectionsImpact of Atopic Dermatitis (Eczema) and Its Treatment on the Risk of Adverse Events Following Total Knee Arthroplasty
Smith-Voudouris J, Dhodapkar M, Halperin S, Cohen J, Grauer J. Impact of Atopic Dermatitis (Eczema) and Its Treatment on the Risk of Adverse Events Following Total Knee Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e23.00267. PMID: 39436712, PMCID: PMC11498930, DOI: 10.5435/jaaosglobal-d-23-00267.Peer-Reviewed Original ResearchConceptsAtopic dermatitisAdverse eventsOdds of pneumoniaTotal knee arthroplastyPerioperative outcomes of patientsModerate-to-severe diseaseIncreased oddsEmergency departmentUrinary tract infectionChronic inflammatory skin conditionOutcomes of patientsLog-rank testRisk of adverse eventsInflammatory skin conditionIncreased odds of pneumoniaKnee arthroplastyTotal knee arthroplasty patientsPerioperative outcomesImmunosuppressive medicationsTract infectionsAggregate adverse eventsAdult patientsImpact of atopic dermatitisPatient characteristicsMultivariate analysisPatients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair
Rancu A, Katsnelson B, Sanchez J, Winter A, Vasudevan R, Grauer J. Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair. JSES International 2024 DOI: 10.1016/j.jseint.2024.09.018.Peer-Reviewed Original ResearchRotator cuff repairPostoperative adverse eventsAdverse eventsArthroscopic rotator cuff repairCurrent Procedural TerminologyElixhauser Comorbidity IndexOccurrence of wound dehiscenceEmergency departmentUrinary tract infectionSymptomatic rotator cuff tearsAssociated with increased riskCuff repairLog-rank testYear of surgerySurgical site infectionSevere adverse eventsKaplan-Meier curvesAcute kidney injuryOccurrence of sepsisDeep vein thrombosisMinor adverse eventsRotator cuff repair patientsIndividual adverse eventsOdds of ED utilizationDiagnosis of fibromyalgiaP27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infectionsAnatomic vs. reverse total shoulder arthroplasty: usage trends and perioperative outcomes
Halperin S, Dhodapkar M, Kim L, Modrak M, Medvecky M, Donohue K, Grauer J. Anatomic vs. reverse total shoulder arthroplasty: usage trends and perioperative outcomes. Seminars In Arthroplasty JSES 2024, 34: 91-96. DOI: 10.1053/j.sart.2023.08.014.Peer-Reviewed Original ResearchTotal shoulder arthroplastyElixhauser Comorbidity IndexPerioperative outcomesAdverse eventsSurgeon volumeShoulder arthroplastyHigher Elixhauser comorbidity indexPerioperative adverse eventsSevere adverse eventsUrinary tract infectionCommon orthopaedic proceduresMatching of patientsPatient demographicsTract infectionsPearlDiver databaseMultivariable analysisOverall incidencePatient populationKidney infectionMerit further investigationOrthopedic proceduresGreater oddsRTSAIncreased percentagePatients
2023
Patients With Cystic Fibrosis Undergoing Total Hip and Total Knee Arthroplasty Are at Increased Risk for Perioperative Complications
Halperin S, Dhodapkar M, Radford Z, Kaszuba S, Rubin L, Grauer J. Patients With Cystic Fibrosis Undergoing Total Hip and Total Knee Arthroplasty Are at Increased Risk for Perioperative Complications. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 32: 309-315. PMID: 38165956, DOI: 10.5435/jaaos-d-23-00783.Peer-Reviewed Original ResearchTotal knee arthroplastyTotal hip arthroplastyUrinary tract infectionPostoperative eventsCystic fibrosisPerioperative outcomesAdverse eventsTract infectionsPleural effusionKnee arthroplastyControl subjectsRevision rateAcute kidney injuryElixhauser Comorbidity IndexRisk of surgeryMultivariable logistic regressionComorbidity indexKidney injuryPerioperative complicationsRespiratory failureTKA patientsCardiac eventsPearlDiver databaseImplant survivalTotal hipPatients With Down Syndrome and Total Hip and Total Knee Arthroplasty: Outcome Measures Show Increased Risk of Perioperative Complications
Halperin S, Dhodapkar M, Radford Z, Frumberg D, Rubin L, Grauer J. Patients With Down Syndrome and Total Hip and Total Knee Arthroplasty: Outcome Measures Show Increased Risk of Perioperative Complications. JAAOS Global Research And Reviews 2023, 7: e23.00108. PMID: 38054749, PMCID: PMC10697628, DOI: 10.5435/jaaosglobal-d-23-00108.Peer-Reviewed Original ResearchConceptsTotal knee arthroplastyTotal hip arthroplastyAcute kidney injuryUrinary tract infectionAdverse eventsDown syndromePostoperative eventsKnee arthroplastyRevision ratePerioperative risk assessmentMinor adverse eventsOutcomes of patientsMultivariable logistic regressionTotal joint arthroplastyPatient/family counselingKidney injuryPerioperative complicationsTKA patientsAdult patientsTract infectionsDS patientsIncreased riskTotal hipCare pathwayJoint arthroplastyTotal Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates
Day W, Jayaram R, Rubin L, Grauer J. Total Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates. The Journal Of Arthroplasty 2023, 39: s275-s278. PMID: 37952742, DOI: 10.1016/j.arth.2023.10.052.Peer-Reviewed Original ResearchTotal hip arthroplastyAdverse eventsMarfan syndromeMultivariable analysisHip arthroplastyUnderwent total hip arthroplastyPostoperative adverse eventsVenous thromboembolic eventsPerioperative care pathwaysUrinary tract infectionConnective tissue diseaseLog-rank testRare disease populationComorbidity indexThromboembolic eventsCardiac eventsPostoperative courseTract infectionsAdult patientsTissue diseaseHip pathologyRevision rateCare pathwayDisease populationGreater oddsAdverse Events After Ankle Fracture Open Reduction Internal Fixation Among Patients With and Without Documented Cannabis and Tobacco Use
Dhodapkar M, Oghenesume O, Halperin S, Modrak M, Yoo B, Grauer J. Adverse Events After Ankle Fracture Open Reduction Internal Fixation Among Patients With and Without Documented Cannabis and Tobacco Use. Foot & Ankle International 2023, 44: 941-948. PMID: 37698277, DOI: 10.1177/10711007231189698.Peer-Reviewed Original ResearchConceptsOpen reduction internal fixationAnkle fracture open reduction internal fixationUrinary tract infectionMinor adverse eventsAdverse eventsReduction internal fixationRetrospective database studyTobacco useAnkle fracturesInternal fixationTobacco usersHigher oddsDatabase studyGreater oddsAnkle open reduction internal fixationElixhauser comorbidity index scoreCause adverse eventsComorbidity Index scoreSevere adverse eventsCommon orthopedic injuriesMultivariable logistic regressionStudy inclusion criteriaGroup of nonusersPerioperative outcomesAdult patientsTiming of Adverse Events Within 90 Days of Hip Fracture Surgery: A Database Study
Kammien A, Ratnasamy P, Caruana D, Grauer J. Timing of Adverse Events Within 90 Days of Hip Fracture Surgery: A Database Study. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 245-251. PMID: 36821080, DOI: 10.5435/jaaos-d-22-00368.Peer-Reviewed Original ResearchConceptsHip fracture surgeryTime of diagnosisAdverse eventsFracture surgeryDay 31Hip fracture surgery patientsElixhauser comorbidity index scoreAcute kidney injuryCommon adverse eventsComorbidity Index scorePatients 65 yearsPostoperative day 0Surgical site infectionUrinary tract infectionPostoperative day 30Specific adverse eventsKidney injuryCardiac eventsSurgery patientsTract infectionsVenous thromboembolismSite infectionPatient counselingNotable morbidityDatabase study
2022
Outcomes Following Total Hip Arthroplasty in Patients With Postpolio Syndrome: A Matched Cohort Analysis
Mercier MR, Moore HG, Wolfstadt JI, Rubin LE, Grauer JN. Outcomes Following Total Hip Arthroplasty in Patients With Postpolio Syndrome: A Matched Cohort Analysis. The Journal Of Arthroplasty 2022, 37: 1822-1826. PMID: 35447277, DOI: 10.1016/j.arth.2022.04.016.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyPostpolio syndromeUrinary tract infectionPPS patientsControl patientsProsthetic dislocationTract infectionsRevision arthroplastyHip arthroplastyFive-year postoperative periodMatched Cohort AnalysisFive-year incidencePostoperative adverse eventsLong-term outcomesBasis of ageComorbidity burdenAdverse eventsPatient demographicsPostoperative periodPostoperative surveillanceHospital readmissionHip arthritisControl cohortAdministrative databasesCohort analysisUnicompartmental Knee Arthroplasty in Octogenarians: A National Database Analysis Including Over 700 Octogenarians
Moore HG, Schneble CA, Kahan JB, Grauer JN, Rubin LE. Unicompartmental Knee Arthroplasty in Octogenarians: A National Database Analysis Including Over 700 Octogenarians. Arthroplasty Today 2022, 15: 55-60. PMID: 35399988, PMCID: PMC8991237, DOI: 10.1016/j.artd.2022.02.009.Peer-Reviewed Original ResearchUnicompartmental knee arthroplastyAdverse eventsMedical comorbiditiesKnee arthroplastyNational Surgical Quality Improvement Program databaseLarge national surgical databaseQuality Improvement Program databaseHigher comorbidity burdenMinor adverse eventsPostoperative adverse eventsSerious adverse eventsImprovement Program databaseProlonged hospital stayUrinary tract infectionDay of surgeryNational database analysisNational surgical databaseShort-term mortalityMultivariate regression analysisComorbidity burdenOctogenarian cohortHospital lengthHospital stayNonhome dischargeSelect patientsAdverse Events After Posterior Lumbar Fusion Are Not Sufficiently Characterized With 30-day Follow-up: A Database Study
Kammien AJ, Zhu JR, Gillinov SM, Gouzoulis MJ, Grauer JN. Adverse Events After Posterior Lumbar Fusion Are Not Sufficiently Characterized With 30-day Follow-up: A Database Study. Journal Of The American Academy Of Orthopaedic Surgeons 2022, 30: 528-533. PMID: 35234736, DOI: 10.5435/jaaos-d-21-01121.Peer-Reviewed Original ResearchConceptsPosterior lumbar fusionTime of diagnosisAdverse eventsLumbar fusionIndividual adverse outcomesNinety-day ratesAcute kidney injurySurgical site infectionUrinary tract infectionSpecific adverse eventsMultiple adverse eventsPLF patientsKidney injuryCardiac eventsTract infectionsVenous thromboembolismPostoperative periodSite infectionAdverse outcomesPatient counselingAdministrative data setsDatabase studyDay 0Time pointsInterquartile range
2021
Total Hip Arthroplasty in Patients With Cerebral Palsy: A Matched Comparison of 90-Day Adverse Events and 5-Year Implant Survival
Moore HG, Gardezi M, Burroughs PJ, Rubin LE, Frumberg DB, Grauer JN. Total Hip Arthroplasty in Patients With Cerebral Palsy: A Matched Comparison of 90-Day Adverse Events and 5-Year Implant Survival. The Journal Of Arthroplasty 2021, 36: 3534-3537. PMID: 34176692, DOI: 10.1016/j.arth.2021.05.039.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyFive-year implant survivalUrinary tract infectionCerebral palsyImplant survivalAdverse eventsTract infectionsComorbid factorsPeriprosthetic fracturesHigher oddsHip arthroplastyPerioperative urinary tract infectionNinety-day incidencePerioperative adverse eventsLong-term outcomesLog-rank testKaplan-Meier plotsMultivariate logistic regressionPerioperative complicationsPostoperative complicationsCP cohortHospital readmissionMatched ComparisonAdministrative databasesPatients
2020
Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications.
Galivanche AR, Kebaish KJ, Adrados M, Ottesen TD, Varthi AG, Rubin LE, Grauer JN. Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications. Journal Of The American Academy Of Orthopaedic Surgeons 2020, 28: 342-351. PMID: 31567615, DOI: 10.5435/jaaos-d-19-00104.Peer-Reviewed Original ResearchConceptsPostoperative pressure ulcersHip fracture surgeryPostoperative complicationsPressure ulcersRisk factorsPreoperative comorbiditiesFracture surgerySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseGeriatric hip fracture patientsGeriatric hip fracture surgeryQuality Improvement Program databaseMultivariate regressionNSQIP Participant Use FilePreoperative risk factorsHip fracture patientsImprovement Program databaseUrinary tract infectionElevated platelet countInsulin-dependent diabetesParticipant Use FilePressure ulcer developmentQuality Improvement ProgramPostoperative deliriumPostoperative pneumonia
2019
The Use of Older Versus Newer Data in the National Surgical Quality Improvement Program Database Influences the Results of Total Hip Arthroplasty Outcomes Studies
Shultz BN, Galivanche AR, Ottesen TD, Bovonratwet P, Grauer JN. The Use of Older Versus Newer Data in the National Surgical Quality Improvement Program Database Influences the Results of Total Hip Arthroplasty Outcomes Studies. JAAOS Global Research And Reviews 2019, 3: e19.00108. PMID: 31773075, PMCID: PMC6855500, DOI: 10.5435/jaaosglobal-d-19-00108.Peer-Reviewed Original ResearchLength of stayUrinary tract infectionPerioperative outcomesTHA patientsPreoperative characteristicsTract infectionsERA groupDeep vein thrombosis/thrombophlebitisNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseArthroplasty outcome studiesImprovement Program databaseMultivariate Poisson regressionNSQIP data setsUnplanned reintubationBlood transfusionNSQIP dataNSQIP variablesProgram databaseOutcome studiesArthroplasty studiesMultivariate analysisPoisson regressionDemographic dataPatientsElective Total Shoulder Arthroplasty in Octogenarians: A Safe Procedure.
Bovonratwet P, Malpani R, Ondeck NT, Tyagi V, Grauer JN. Elective Total Shoulder Arthroplasty in Octogenarians: A Safe Procedure. Journal Of The American Academy Of Orthopaedic Surgeons 2019, 27: 145-154. PMID: 30252789, DOI: 10.5435/jaaos-d-17-00364.Peer-Reviewed Original ResearchConceptsPrimary total shoulder arthroplastyTotal shoulder arthroplastyNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseImprovement Program databasePerioperative complicationsHospital stayProgram databaseShoulder arthroplastyElective total shoulder arthroplastyPropensity score-matched comparisonYoung populationRate of readmissionUrinary tract infectionPost-discharge careOctogenarian patientsPreoperative optimizationOctogenarian populationPerioperative coursePatient characteristicsTract infectionsSafe procedureRisk factorsOctogenariansReadmission
2018
Adverse Events Following Posterior Lumbar Fusion: A Comparison of Spine Surgeons Perceptions and Reported Data for Rates and Risk Factors.
Ondeck NT, Bohl DD, Bovonratwet P, McLynn RP, Cui JJ, Samuel AM, Webb ML, Grauer JN. Adverse Events Following Posterior Lumbar Fusion: A Comparison of Spine Surgeons Perceptions and Reported Data for Rates and Risk Factors. The International Journal Of Spine Surgery 2018, 12: 603-610. PMID: 30364864, PMCID: PMC6198632, DOI: 10.14444/5074.Peer-Reviewed Original ResearchPosterior lumbar fusionPatient risk factorsAdverse eventsRisk factorsPatient factorsLumbar fusionDegenerative conditionsElective posterior lumbar fusionSpine surgeons’ perceptionPostoperative adverse eventsAdverse event ratesUrinary tract infectionDeep vein thrombosisInsulin-dependent diabetesPostoperative complicationsCurrent smokingTract infectionsVein thrombosisDependent diabetesNSQIP dataExpectation settingInclusion criteriaAmerican CollegeSpine surgeonsEvent rates