2024
Goldenhar syndrome associated with increased risk of respiratory failure and reoperations following spinal deformity surgery
Gouzoulis M, Jabbouri S, Seddio A, Grauer J, Tuason D. Goldenhar syndrome associated with increased risk of respiratory failure and reoperations following spinal deformity surgery. Spine Deformity 2024, 1-6. PMID: 39249241, DOI: 10.1007/s43390-024-00963-3.Peer-Reviewed Original ResearchAdolescent idiopathic scoliosisPosterior spinal fusionGoldenhar syndromeAdverse eventsRespiratory failureSpinal fusionDeformity surgeryIncreasing odds of respiratory failureOdds ratioRisk of respiratory failureOdds of respiratory failureIncidence of adverse eventsIncidence of reoperationSpinal deformity surgeryRisk of adverse eventsSevere adverse eventsPostoperative adverse eventsMultivariate logistic regressionAssociated with scoliosisNational sample of patientsSample of patientsBackgroundGoldenhar syndromeSpinal manifestationsElixhauser Comorbidity IndexPearlDiver database
2023
Do Children With Medicaid Insurance Have Increased Revision Rates 5 Years After Posterior Spinal Fusions?
Moore H, Patibandla S, McClung A, Grauer J, Sucato D, Wise C, Johnson M, Rathjen K, McIntosh A, Ramo B, Brooks J. Do Children With Medicaid Insurance Have Increased Revision Rates 5 Years After Posterior Spinal Fusions? Journal Of Pediatric Orthopaedics 2023, 43: 615-619. PMID: 37694695, DOI: 10.1097/bpo.0000000000002504.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionAdolescent idiopathic scoliosisMedicaid insurancePrivate insuranceRevision surgerySpinal fusionInternational ClassificationBaseline medical comorbiditiesKaplan-Meier analysisLog-rank testSegmental spinal instrumentationLong fusion constructsBaseline comorbiditiesIndependent t-testIndex surgeryMedical comorbiditiesPostoperative complicationsCause revisionCohort studyNinth RevisionAIS patientsRevision codesPrimary diagnosisHigh prevalenceMedicaid patientsDecline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”
Rudisill K, Ratnasamy P, Maloy G, Grauer J. Decline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 938-944. PMID: 37332184, DOI: 10.5435/jaaos-d-22-01029.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexSurgeon specialtySpinal fusionComorbidity indexSmoking statusGold standardIliac crest autograftPatient ageIndependent predictorsPatient factorsNonsurgical factorsCrest autograftSpine surgeryBone graftingSpine fusionIliac crestBone graftAutograftYounger ageSurgeryInsurance factorsSpinal boneCommon procedureInsurance plansAge
2022
Marfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery
Joo PY, Caruana DL, Gouzoulis MJ, Moore HG, Zhu JR, Ameri B, Grauer JN. Marfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery. Spine Deformity 2022, 10: 1169-1174. PMID: 35362940, DOI: 10.1007/s43390-022-00501-z.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisMarfan syndromeReoperation rateAIS patientsOdds ratioMFS patientsFive-Year Reoperation RatesNinety-day outcomesMinor adverse eventsMultivariate odds ratiosPosterior spinal fusionSpinal deformity surgeryComorbidity indexAdverse eventsDeformity surgeryAdministrative databasesRelative riskSpinal fusionIdiopathic scoliosisPatientsRepresentative sampleAgeOutcomesSexReadmission
2020
Use of intraoperative navigation for posterior spinal fusion in adolescent idiopathic scoliosis surgery is safe to consider
Moore HG, Samuel AM, Burroughs PJ, Pathak N, Tuason DA, Grauer JN. Use of intraoperative navigation for posterior spinal fusion in adolescent idiopathic scoliosis surgery is safe to consider. Spine Deformity 2020, 9: 403-410. PMID: 33025389, DOI: 10.1007/s43390-020-00218-x.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisNon-navigated patientsPerioperative adverse outcomesPosterior spinal fusionUse of navigationPosterior fusionAdverse outcomesSpinal fusionShort-term adverse eventsPost-operative hospital stayAdolescent idiopathic scoliosis surgeryStereotactic navigationNon-navigated casesNSQIP-Pediatric databaseThirty-day outcomesYear of procedureLonger operative timeIdiopathic scoliosis surgeryLength of stayIntraoperative navigationNational pediatric databaseHospital stayPerioperative outcomesAdverse eventsPediatric patients
2017
After Posterior Fusions for Adult Spinal Deformity, Operative Time is More Predictive of Perioperative Morbidity, Rather Than Surgical Invasiveness
Samuel AM, Fu MC, Anandasivam NS, Webb ML, Lukasiewicz AM, Kim HJ, Grauer JN. After Posterior Fusions for Adult Spinal Deformity, Operative Time is More Predictive of Perioperative Morbidity, Rather Than Surgical Invasiveness. Spine 2017, 42: 1880-1887. PMID: 28538595, DOI: 10.1097/brs.0000000000002243.Peer-Reviewed Original ResearchConceptsAdult spinal deformityPosterior spinal fusionOperative timeSurgical invasivenessSpinal deformitySpinal fusionMultivariate analysisPerioperative outcomesPosterior fusionOperative timingNational Surgical Quality Improvement Program databaseIndependent effectsQuality Improvement Program databaseImprovement Program databaseRetrospective cohort studyLonger operative timeOverall operative timeAdult deformity surgeryInvasive surgical proceduresInpatient complicationsPerioperative complicationsPerioperative morbidityAdult patientsCohort studyDeformity surgeryWhich Pediatric Orthopaedic Procedures Have the Greatest Risk of Adverse Outcomes?
Basques BA, Lukasiewicz AM, Samuel AM, Webb ML, Bohl DD, Smith BG, Grauer JN. Which Pediatric Orthopaedic Procedures Have the Greatest Risk of Adverse Outcomes? Journal Of Pediatric Orthopaedics 2017, 37: 429-434. PMID: 26558959, DOI: 10.1097/bpo.0000000000000683.Peer-Reviewed Original ResearchConceptsPediatric orthopaedic proceduresCommon pediatric orthopaedic proceduresAdverse outcomesAdverse eventsOrthopedic proceduresSpinal fusionPediatric patientsPediatric databaseNational Surgical Quality Improvement Program Pediatric databaseSurgeons National Surgical Quality Improvement Program Pediatric databaseNSQIP-Pediatric databasePediatric orthopedic patientsRetrospective cohort studyMultiple patient characteristicsPosterior spinal fusionPediatric patient samplesDifferent orthopedic proceduresASA classCohort studyPerioperative safetyPatient characteristicsNonidiopathic scoliosisOrthopedic patientsOperative characteristicsExternal fixation
2016
Predicting Short-Term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis: Table 1.
Basques B, Golinvaux N, Smith B, Bohl D, Grauer J. Predicting Short-Term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis: Table 1. Pediatrics 2016, 137: 539a-539a. DOI: 10.1542/peds.137.supplement_3.539a.Peer-Reviewed Original Research
2015
Predicting Short-term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis
Basques BA, Chung SH, Lukasiewicz AM, Webb ML, Samuel AM, Bohl DD, Smith BG, Grauer JN. Predicting Short-term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis. Spine 2015, 40: 1910-1917. PMID: 26261918, DOI: 10.1097/brs.0000000000001093.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionSevere adverse eventsShort-term morbidityNeuromuscular scoliosisAdverse eventsRisk factorsInfectious complicationsASA classificationSpinal fusionNational Surgical Quality Improvement Program Pediatric databaseSurgeons National Surgical Quality Improvement Program Pediatric databaseOnly independent risk factorPoor short-term outcomeShort-term adverse outcomesPrevious cardiac surgeryRetrospective cohort studyIndependent risk factorOnly risk factorShort-term outcomesBody mass indexNMS patientsAnesthesiologists classificationCohort studyPatient characteristicsCardiac surgeryPoor visualization limits diagnosis of proximal junctional kyphosis in adolescent idiopathic scoliosis
Basques BA, Long WD, Golinvaux NS, Bohl DD, Samuel AM, Lukasiewicz AM, Webb ML, Grauer JN. Poor visualization limits diagnosis of proximal junctional kyphosis in adolescent idiopathic scoliosis. The Spine Journal 2015, 17: 784-789. PMID: 26523958, DOI: 10.1016/j.spinee.2015.10.040.Peer-Reviewed Original ResearchConceptsProximal junctional kyphosisProximal junctional angleAdolescent idiopathic scoliosisUpper instrumented vertebraIntra-class correlation coefficientJunctional kyphosisInter-rater reliabilityIdiopathic scoliosisRetrospective cohort studyPosterior instrumented fusionExclusion of patientsSagittal Cobb anglePosterior spinal fusionIntra-rater reliabilityCohort studyInstrumented fusionAIS patientsSingle institutionPostoperative filmsSpinal fusionCobb angleUpright filmsPoor visualizationPatientsDiagnosisPredicting Short-Term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis
Basques B, Lukasiewicz A, Webb M, Samuel A, Bohl D, Smith B, Grauer J. Predicting Short-Term Morbidity in Patients Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis. The Spine Journal 2015, 15: s224. DOI: 10.1016/j.spinee.2015.07.322.Peer-Reviewed Original Research
2014
Administrative Database Concerns
Golinvaux NS, Bohl DD, Basques BA, Grauer JN. Administrative Database Concerns. Spine 2014, 39: 2019-2023. PMID: 25202941, DOI: 10.1097/brs.0000000000000598.Peer-Reviewed Original ResearchConceptsICD-9 codesCross-sectional studyPreoperative anemiaICD-9 codingPreoperative hematocritNationwide Inpatient SampleNinth Revision codesAcademic medical centerNegative predictive valueAdditional comorbiditiesRevision codesInpatient SampleAdministrative databasesSpine surgerySpinal fusionBACKGROUND DATAMedical CenterInternational ClassificationICD-9Normal rangePatientsPredictive valueLarger sample sizeAnemiaNational databaseShort-Term Adverse Events, Length of Stay, and Readmission After Iliac Crest Bone Graft for Spinal Fusion
Gruskay JA, Basques BA, Bohl DD, Webb ML, Grauer JN. Short-Term Adverse Events, Length of Stay, and Readmission After Iliac Crest Bone Graft for Spinal Fusion. Spine 2014, 39: 1718-1724. PMID: 24979140, DOI: 10.1097/brs.0000000000000476.Peer-Reviewed Original ResearchConceptsIliac crest bone graftLength of stayPostoperative blood transfusionAdverse eventsCrest bone graftReadmission ratesBlood transfusionOperative timeSpinal fusionMultivariate analysisICBG cohortBone graftRetrospective cohort studyShort-term morbidityTerm adverse eventsShort-term outcomesBone graft harvestBivariate logistic regressionDonor site morbidityDatabase cohortCohort studySurgical dataSurgical timeGraft harvestBACKGROUND DATA
2013
Methods of evaluating lumbar and cervical fusion
Gruskay JA, Webb ML, Grauer JN. Methods of evaluating lumbar and cervical fusion. The Spine Journal 2013, 14: 531-539. PMID: 24183750, DOI: 10.1016/j.spinee.2013.07.459.Peer-Reviewed Original ResearchConceptsFlexion/extension radiographsCases of pseudarthrosisDiagnosis of pseudarthrosisFocused clinical assessmentFirst postoperative yearBone graft optionsPreferred imaging modalityAssessment of motionPostoperative yearRadicular symptomsCommon complicationCervical fusionGraft optionsExtension radiographsClinical assessmentClinical failureSurgical techniqueSpinal fusionSpinal arthrodesisComputed tomographyClinical practicePseudarthrosisSignificant causeDiagnosisUse of instrumentation
2010
Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion.
Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. The American Journal Of Orthopedics 2010, 39: 531-8. PMID: 21623419.Peer-Reviewed Original ResearchConceptsFusion rateGraft alternativesPosterolateral lumbar spinal fusionLumbar spinal fusionRhBMP-2Spine fusion modelDose-response curveEctopic bone formation modelBone graft alternativesStudy ratsLumbar fusionRat modelSpinal fusionSpine fusionB graftsRecombinant human bone morphogenetic protein-2Manual palpationHuman bone morphogenetic protein-2Bone matrix productsSignificant differencesProtein 2DBM carrierBone matrixAutograftBone morphogenetic protein-2
2006
Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model
Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN. Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model. The Spine Journal 2006, 6: 385-390. PMID: 16825043, DOI: 10.1016/j.spinee.2005.10.010.Peer-Reviewed Original ResearchConceptsSerum osteocalcin levelsParathyroid hormoneOsteocalcin levelsFusion rateDaily injectionsManual palpationLumbar fusionRat modelIntertransverse process spinal fusionDaily parathyroid hormoneSpinal fusion outcomesPosterolateral lumbar fusionIliac crest autograftSprague-Dawley ratsPreclinical animal studiesGreater fusion rateGreat clinical valuePlacebo groupIntermittent administrationSerum osteocalcinCrest autograftAnabolic effectsSpinal fusionInjectable agentsClinical value
2005
Animal models for spinal fusion
Drespe IH, Polzhofer GK, Turner AS, Grauer JN. Animal models for spinal fusion. The Spine Journal 2005, 5: s209-s216. PMID: 16291115, DOI: 10.1016/j.spinee.2005.02.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2004
Posterolateral lumbar fusions in athymic rats: characterization of a model
Grauer JN, Bomback DA, Lugo R, Troiano NW, Patel TC, Friedlaender GE. Posterolateral lumbar fusions in athymic rats: characterization of a model. The Spine Journal 2004, 4: 281-286. PMID: 15125850, DOI: 10.1016/j.spinee.2003.10.001.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusion modelAthymic ratsManual palpationPosterolateral lumbar fusionL4-L5 levelSmall animal modelsPotential inflammatory responseLumbar fusionInflammatory responseSpinal fusionHistology resultsAutograft fusionAnimal modelsFusion rateOsteoinductive productsRatsIntertransverse fusionPalpationSurvival surgeryGraftWeeksComparison of FusionSpontaneous fusionLimited utilityXenogenic proteins
2003
Indications, techniques, and outcomes of posterior surgery for chronic low back pain
Kwon B, Vaccaro AR, Grauer JN, Beiner J. Indications, techniques, and outcomes of posterior surgery for chronic low back pain. Orthopedic Clinics Of North America 2003, 34: 297-308. PMID: 12914269, DOI: 10.1016/s0030-5898(03)00014-2.ChaptersConceptsChronic low back painLow back painBack painPosterior lumbar spine surgeryLow back pain sufferersRole of surgeryLumbar spine surgerySatisfactory clinical outcomesBack pain sufferersDegenerative disc diseaseHigh fusion rateInterbody fusion proceduresNonoperative therapyPosterior surgeryClinical outcomesSurgical interventionLumbar fusionDisc diseaseSpine surgeryDiagnostic modalitiesPain sufferersSpinal fusionArthrodesis techniquePainSpine surgeons
2002
Evaluation of OP-1 in a rabbit model of lumbar fusions
Patel T, Grauer J, Erulkar J. Evaluation of OP-1 in a rabbit model of lumbar fusions. Progress In Inflammation Research 2002, 207-222. DOI: 10.1007/978-3-0348-8121-0_11.Peer-Reviewed Original Research