2019
Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Eubanks HB, Lavoie EG, Goree J, Kamykowski JA, Gokden N, Fausther M, Dranoff JA. Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells. Gene Expression 2019, 20: 25-37. PMID: 31757226, PMCID: PMC7284106, DOI: 10.3727/105221619x15742818049365.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonActin Depolymerizing FactorsActinsAnimalsCarbon TetrachlorideCell LineCell MovementCell SeparationGene Knockdown TechniquesHepatic Stellate CellsHumansLiverLiver CirrhosisMiceMyofibroblastsQb-SNARE ProteinsQc-SNARE ProteinsRho-Associated KinasesRNA InterferenceRNA, Small InterferingSignal TransductionStress FibersWound HealingConceptsSNAP-23T-SNARE proteinsSpecific SNARE proteinsMyofibroblastic hepatic stellate cellsSNARE proteinsActin cytoskeletonActin dynamicsHepatic stellate cellsCytoskeletal reorganizationCell movementPlasma membraneHomologous proteinsExtracellular environmentMicrofilament organizationSNAP-25HSC phenotypeReceptor proteinProteinStellate cellsQuiescent hepatic stellate cellsPhenotypeCellsCritical effector cellsCytoskeletonVivo
2014
NT5E Mutations That Cause Human Disease Are Associated with Intracellular Mistrafficking of NT5E Protein
Fausther M, Lavoie EG, Goree JR, Baldini G, Dranoff JA. NT5E Mutations That Cause Human Disease Are Associated with Intracellular Mistrafficking of NT5E Protein. PLOS ONE 2014, 9: e98568. PMID: 24887587, PMCID: PMC4041762, DOI: 10.1371/journal.pone.0098568.Peer-Reviewed Original ResearchConceptsHuman diseasesWild typeCOS-7 kidney cellsWild-type proteinNovel genetic causesSubcellular traffickingER retentionMalachite green assayHeterologous expressionType proteinDefective proteinMutant fusionTrafficking defectsPlasma membraneExtracellular environmentGene mutationsDegradation of AMPBiochemical activityConfocal immunofluorescenceDistinct familiesWestern blot analysisCatalytic functionSynthetic apparatusMutant humanCell surface