2021
Direct antiviral agents for chronic hepatitis C virus infection improve health-related quality of life significantly in the long term
Atamla M, Khoury J, Dabbah I, Kramsky R, Yaacob A, Veitsman E, Saadi T. Direct antiviral agents for chronic hepatitis C virus infection improve health-related quality of life significantly in the long term. Clinical And Experimental Hepatology 2021, 7: 258-263. PMID: 34712826, PMCID: PMC8527337, DOI: 10.5114/ceh.2021.109192.Peer-Reviewed Original ResearchDirect antiviral agentsChronic hepatitis C virus (HCV) infectionHepatitis C virus infectionQuality of lifeC virus infectionHealth-related qualitySuccessful treatmentVirus infectionAntiviral agentsChronic HCV infectionDAA treatmentExtrahepatic manifestationsHCV infectionLiver diseaseLong termLiver fibrosisObservational studyProfound negative impactNew drugsInfectionHRQLTreatmentAverage timePatientsDrugsPoint Shear Wave Elastography for Assessing Liver Stiffness in Chronic Liver Diseases of Different Etiologies Compared to Biopsy.
Saadi T, Khoury J, Toukan W, Krimasky R, Veitsman E, Baruch Y, Gaitini D, Beck-Razi N. Point Shear Wave Elastography for Assessing Liver Stiffness in Chronic Liver Diseases of Different Etiologies Compared to Biopsy. Israel Medical Association Journal 2021, 23: 223-228. PMID: 33899354.Peer-Reviewed Original ResearchConceptsChronic liver diseaseLiver diseaseLiver stiffnessDifferent etiologiesControl groupViral hepatitisLiver biopsyBiopsy resultsFibrosis degreeStudy groupMedian stiffnessShear wave elastographyHealthy adultsProspective single-center studyNon-significant fibrosisNon-viral hepatitisSingle-center studyLiver biopsy resultsMETAVIR scoring systemPoint shear wave elastographyPSWE measurementsAdult patientsSubgroup analysisLiver fibrosisHealthy controls
2020
Histomorphometric Findings May Help Predicting Response in Patients with Chronic Liver Disease.
Abu Raya M, Klein A, Sabo E, Yaccob A, Baruch Y, Khoury J, Saadi T. Histomorphometric Findings May Help Predicting Response in Patients with Chronic Liver Disease. Israel Medical Association Journal 2020, 22: 320-325. PMID: 32378826.Peer-Reviewed Original ResearchConceptsHepatitis C virusViral responseInflammatory cellsChronic hepatitis C virusChronic HCV infectionChronic liver diseaseEra of treatmentLiver needle biopsyNon-SVRHCV infectionCollagen fibersLiver unitPeg-interferonLiver diseaseHistological findingsC virusHistomorphometric findingsLeading causeNeedle biopsyHistological variablesPatient responseLiver architectureTreatment responseHepatocellular carcinomaPrevious patients
2018
Is There a Relationship Between Treatment With Direct Antiviral Agents for HCV Infection and the Development of Malignancies?
Saadi T, Khoury J. Is There a Relationship Between Treatment With Direct Antiviral Agents for HCV Infection and the Development of Malignancies? Journal Of Clinical Gastroenterology 2018, 52: 353-359. PMID: 28590324, DOI: 10.1097/mcg.0000000000000853.Peer-Reviewed Original ResearchConceptsDirect antiviral agentsAdverse eventsHepatocellular carcinomaAntiviral agentsChronic hepatitis C virus (HCV) infectionParitaprevir/ritonavir/ombitasvirHepatitis C virus infectionDe novo hepatocellular carcinomaLarge clinical trial dataSerum HCV RNAC virus infectionNovo hepatocellular carcinomaTreatment of choiceTransitional cell carcinomaAggressive hepatocellular carcinomaAggressive transitional cell carcinomaClinical trial dataDevelopment of malignancyHCV infectionHCV RNAHCV genotypesLiver diseaseCell carcinomaLaryngeal carcinomaPancreatic adenocarcinomaGlycogenic hepatopathy
Khoury J, Zohar Y, Shehadeh N, Saadi T. Glycogenic hepatopathy. Hepatobiliary & Pancreatic Diseases International 2018, 17: 113-118. PMID: 29709217, DOI: 10.1016/j.hbpd.2018.02.006.Peer-Reviewed Original ResearchConceptsGlycogenic hepatopathyLiver biopsyLiver diseaseRight upper quadrant abdominal painUpper quadrant abdominal painEnd-stage liver diseaseNonalcoholic fatty liver diseaseUncontrolled diabetes mellitusQuadrant abdominal painFatty liver diseaseRoutine blood testsTight glycemic controlLiver glycogen accumulationPubMed database searchAbdominal painClinical responseElevated liverDiabetes mellitusGlycemic controlClinical presentationBlood testsPhysical examinationMedical historyNoninvasive testsLiver enzymes