2017
GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers
Yang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.Peer-Reviewed Original ResearchGenome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1
Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Molecular Psychiatry 2017, 22: 346-352. PMID: 28115739, PMCID: PMC5407902, DOI: 10.1038/mp.2016.257.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAnalgesics, OpioidBlack or African AmericanDose-Response Relationship, DrugFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMethadoneMiddle AgedMorphineOpioid-Related DisordersPainPolymorphism, Single NucleotideReceptors, Opioid, muUnited StatesWhite PeopleConceptsMethadone doseOD subjectsOpioid dependenceSignificant associationDaily methadone doseMethadone maintenance doseOpioid analgesic doseDose of morphineHigher methadone doseDifferent clinical settingsΜ-opioid receptorAnalgesic doseMaintenance doseOral methadoneEffective analgesicSurgical painOpioid sensitivityPrecision pharmacotherapySelective agonistGenome-wide association studiesAA childrenClinical settingDoseMinor alleleOPRM1
1989
Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y
Berrettini W, Garrick N, Nurnberger J, Simmons-Alling S, Gelernter J, Gold P, Rubinow D, Murphy D. Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y. Biological Psychiatry 1989, 26: 623-630. PMID: 2790099, DOI: 10.1016/0006-3223(89)90087-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDose-Response Relationship, DrugGlycopyrrolateHumansInfusions, IntravenousMacaca mulattaNeostigmineNeuropeptide YPhysostigmineConceptsIntravenous infusionMicrograms/Central nervous system neurotransmittersAcute pharmacological challengePharmacological challenge paradigmsAcute intravenous infusionSerial CSF samplesDose-time interactionUseful clinical toolNormal human subjectsCholinergic agonist physostigmineCerebrospinal fluid neuropeptidesCSF NPYPhysostigmine infusionStimulus-induced responsesIntravenous physostigmineCSF levelsCSF cathetersCSF neuropeptidesNeuropeptide changesPharmacological challengeCSF samplesClinical toolRhesus monkeysPhysostigmine