2017
Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center
Rungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. Journal Of Addiction Medicine 2017, 11: 19. PMID: 27649265, PMCID: PMC5291761, DOI: 10.1097/adm.0000000000000262.Peer-Reviewed Original ResearchConceptsMA dependenceMA useLifetime episodesTreatment centersLogistic regression analysisResidential drug treatmentChi-square testSex differencesSemi-Structured AssessmentAntisocial personality disorderMA diagnosisMA withdrawalTreatment cohortsComorbid antisocial personality disorderAssociated FactorsDrug treatmentSex-specific differencesNicotine dependencePsychomotor retardationDrug dependenceLogistic regressionMethamphetamine useMA usersPersonality disorderMethamphetamine
2016
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks
Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry 2016, 73: 472. PMID: 27028160, PMCID: PMC4974817, DOI: 10.1001/jamapsychiatry.2016.0036.Peer-Reviewed Original ResearchConceptsCannabis dependenceNeuronal calcium homeostasisGenetic factorsMajor depressive disorderSushi multiple domains-1 (CSMD1) geneSubstance abuse treatment centersSpecific genetic risk factorsGenetic risk factorsShared genetic riskPotential genetic factorsCentral nervous system developmentCriterion countsCannabis dependence severityDomain 1 geneCAD riskMean ageRisk factorsDepressive disorderNervous system developmentMajor depressionLarge cohortMAIN OUTCOMEGenome-wide association studiesTreatment centersCalcium homeostasis
2014
Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort
Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort. Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.Peer-Reviewed Original ResearchConceptsDopamine β-hydroxylaseMethamphetamine-dependent individualsAssociated clinical variablesGenetic polymorphismsΒ-hydroxylaseLogistic regression analysisSubstance abuse treatment centersHigh-activity genotypesSemi-Structured AssessmentAntisocial personality disorderCT carriersCent of individualsClinical featuresClinical presentationCigarette smokingClinical variablesRetrospective analysisTreatment centersDrug dependenceActivity genotypeMethamphetamine useMethamphetamine dependencePersonality disorderRegression analysisGenetic association