Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter AB, Daughters SB, MacPherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance. Journal Of Psychiatric Research 2011, 46: 87-94. PMID: 22024485, PMCID: PMC3687355, DOI: 10.1016/j.jpsychires.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCatechol O-MethyltransferaseChildChi-Square DistributionDistrict of ColumbiaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansLongitudinal StudiesMaleMood DisordersPolymorphism, Single NucleotidePsychiatric Status Rating ScalesRegression AnalysisRisk-TakingSerotonin Plasma Membrane Transport ProteinsConceptsEmotion regulation difficultiesDistress intoleranceBehavioral measuresPoor psychological functioningAdolescent risk behaviorsDistress tolerancePsychological functioningLarger longitudinal studyVal allele carriersYear old youthMet homozygotesEmotional abuseBehavioral indicatorsBehavioral assessmentLongitudinal studyGenetic influencesCandidate genetic polymorphismsTaskYouthDistressExploratory analysisRisk behaviorsEmpirical evidencePrior studiesDifficultiesEarly-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates
Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. Psychiatry Research 2011, 192: 37-44. PMID: 21377844, PMCID: PMC4090111, DOI: 10.1016/j.pscychresns.2010.11.006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnxietyBehavior, AnimalBrain MappingCorpus CallosumCross-Sectional StudiesFearGene FrequencyGenotypeHippocampusImage Processing, Computer-AssistedLinear ModelsMacaca radiataMagnetic Resonance ImagingMaleSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsBrain developmentNonhuman primatesCorpus callosum measurementsMale bonnet monkeysMiddle temporal gyrus volumeCorpus callosum developmentMale nonhuman primatesEarly life stressReduced hippocampusCorpus callosumMRI measuresBonnet monkeysPsychiatric disordersMRI scansHippocampal volumetricsSerotonin transporter genotypeCC sizeStress paradigmHippocampusStress reactivityMorphometry assessmentBehavioral assessmentTransporter genotypeAnxious behaviorEarly stress