2021
AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury
El-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury. The Journal Of Applied Laboratory Medicine 2021, 6: 1316-1337. PMID: 33973621, DOI: 10.1093/jalm/jfab020.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute kidney injuryKidney injuryNew biomarkersPotential acute kidney injuryInsulin-like growth factor binding protein 7Growth factor binding protein 7Early detectionLong-term complicationsLaboratory investigationsEmergence of biomarkersHealth care costsBinding protein 7AKI alertsKidney damageClinical indicationsCystatin CSudden episodeCare costsTissue inhibitorDiagnostic thresholdMetalloproteinases 2Test utilizationPreponderance of evidenceTraditional markersExpert recommendations
2020
Nephrocheck®: Checkmate or reality check?
El-Khoury JM. Nephrocheck®: Checkmate or reality check? Annals Of Clinical Biochemistry International Journal Of Laboratory Medicine 2020, 58: 3-5. PMID: 33016084, DOI: 10.1177/0004563220967581.Peer-Reviewed Original Research
2019
The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running
Mansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR. The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running. Clinical Journal Of The American Society Of Nephrology 2019, 14: 1297-1305. PMID: 31413064, PMCID: PMC6730516, DOI: 10.2215/cjn.01400219.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultBody Temperature RegulationBody WaterFemaleHumansMaleMiddle AgedProspective StudiesRunningYoung AdultConceptsCore body temperatureBody temperaturePercent of runnersAcute tubular injuryPlasma copeptin concentrationsMajority of runnersContinuous core body temperatureAKIN criteriaDays postmarathonPrior marathonsTransient AKICopeptin concentrationsTubular injuryInjury biomarkersPrimary outcomeProspective cohortNephron damageNegative sodiumUrine microscopyVolume lossUrine sedimentAKIAbstractTextSweat sodiumCopeptin
2018
Erratic Serum Creatinine Concentrations in a Cardiac Patient
Charifa A, Bunch DR, El-Khoury JM. Erratic Serum Creatinine Concentrations in a Cardiac Patient. Clinical Chemistry 2018, 64: 1543-1544. PMID: 30266720, DOI: 10.1373/clinchem.2017.285858.Peer-Reviewed Original Research
2017
Urinalysis findings and urinary kidney injury biomarker concentrations
Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, on behalf of the TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrology 2017, 18: 218. PMID: 28683730, PMCID: PMC5499057, DOI: 10.1186/s12882-017-0629-z.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansInternationalityMaleMiddle AgedProspective StudiesProteinuriaUrinalysisConceptsKidney injury molecule-1Post-operative samplesKidney injuryUrinalysis findingsUrinary biomarkersBiomarker concentrationsPost-operative AKIPre-operative samplesUrine dipstick testingPost-operative time pointsInjury molecule-1Time pointsRenal tubular damageUrinary biomarker concentrationsUrinary biomarker levelsTRIBE-AKI cohortLiver fatty acidClinical AKIDipstick proteinuriaProteinuria concentrationsUrinary NGALAKI biomarkersTubular damageCardiac surgeryNeutrophil gelatinase