1989
The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.
Pinto AL, Steitz JA. The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8742-8746. PMID: 2479028, PMCID: PMC298364, DOI: 10.1073/pnas.86.22.8742.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoproteinU5 small nuclear ribonucleoproteinHeLa cell nuclear extractsSmall nuclear ribonucleoprotein particleCell nuclear extractsAnti-trimethylguanosine antibodyNuclear ribonucleoprotein particleAffinity-purified spliceosomesSplicing proteinsMammalian proteinsYeast proteinsSnRNP complexMRNA splicingSplicing extractsRibonucleoprotein particleNuclear ribonucleoproteinMammalian analogueNuclear extractsSm classGradient fractionationSm epitopesProteinSpliceosomeProtein reactivePrp8
1988
Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.
Montzka KA, Steitz JA. Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 8885-8889. PMID: 2973606, PMCID: PMC282611, DOI: 10.1073/pnas.85.23.8885.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoproteinU12 small nuclear ribonucleoproteinsSm small nuclear ribonucleoproteinsTrimethylguanosine cap structureTwo-dimensional gel fractionationLow-abundance RNAsLower eukaryotesSmall RNAsMRNA processingMammalian cellsMRNA splicingNuclear ribonucleoproteinAdditional speciesCap structureNuclease sensitivityNew RNASm classSm epitopesRNAU11Gel fractionationPotential roleU12EukaryotesSplicing