Featured Publications
SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang Z, Simons M, Min W. SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature Communications 2018, 9: 3303. PMID: 30120232, PMCID: PMC6098000, DOI: 10.1038/s41467-018-05812-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorneaCysteine EndopeptidasesDiabetes MellitusEndopeptidasesGene DeletionGene Knock-In TechniquesGene SilencingGolgi ApparatusHuman Umbilical Vein Endothelial CellsHumansIntracellular SpaceMaleMice, Inbred C57BLMice, KnockoutNeovascularization, PathologicProtein TransportRetinaSignal TransductionSUMO-1 ProteinSumoylationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsPathological angiogenesisPotential therapeutic targetRegulation of VEGFR2Non-sumoylated formEndothelial-specific deletionDiabetic miceHindlimb ischemiaTherapeutic targetDiabetic settingControl of angiogenesisEndothelial cellsAngiogenesisVEGFR2Surface expressionVEGFR2 activityTissue repairSENP1
2015
Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1α-VEGF pathway
Yang C, Xu Y, Zhou H, Yang L, Yu S, Gao Y, Huang Y, Lu L, Liang X. Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1α-VEGF pathway. Molecular Medicine Reports 2015, 13: 1287-1296. PMID: 26676934, DOI: 10.3892/mmr.2015.4679.Peer-Reviewed Original Research
2010
[An improved method of culturing human umbilical vein endothelial cells and its characterization].
Lin S, Zhou H, Ding Y, Liang X, Luo Y, Tang S. [An improved method of culturing human umbilical vein endothelial cells and its characterization]. Yan Ke Xue Bao (2016) 2010, 25: 99-102. PMID: 21186489, DOI: 10.3969/g.issn.1000-4432.2010.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Culture TechniquesCells, CulturedCulture MediaEndothelial CellsEndothelium, VascularHuman Umbilical Vein Endothelial CellsHumansUmbilical VeinsVon Willebrand FactorConceptsHuman umbilical vein endothelial cellsCD31 immunohistochemical stainingHuman umbilical cordUmbilical vein endothelial cellsType ICollagenase type IVein endothelial cellsImmunohistochemical stainingUmbilical cordT-tubeHeparin sodiumEndothelial cellsBasal growth mediumAntigenCell growthCordCD31