2024
SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
Xu Y, Zhang H, Chen Y, Pober J, Zhou M, Zhou J, Min W. SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling. Nature Communications 2024, 15: 6919. PMID: 39134547, PMCID: PMC11319592, DOI: 10.1038/s41467-024-51350-5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSerum response factorCardiovascular diseaseVSMC synthetic phenotypeVascular remodelingNeointimal formationSENP1 deficiencySerum response factor activitySmooth muscle phenotypic switchingPhenotypic switchingPathogenesis of cardiovascular diseaseSmooth muscle cellsPost-translational SUMOylationTreatment of cardiovascular diseasesInhibitor AZD6244Phospho-ELK1Increased nuclear accumulationLysosomal localizationGene transcriptionNuclear accumulationMuscle cellsCoronary arteryCVD patientsVSMC phenotypic switchTherapeutic potential
2017
ASK family in cardiovascular biology and medicine
Liu T, Zhou HJ, Min W. ASK family in cardiovascular biology and medicine. Advances In Biological Regulation 2017, 66: 54-62. PMID: 29107568, PMCID: PMC5705453, DOI: 10.1016/j.jbior.2017.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiovascular DiseasesHumansMAP Kinase Kinase Kinase 5MAP Kinase Kinase KinasesOxidative StressSignal TransductionConceptsProtein kinase signalsMAPK signal cascadeCellular functionsKinase signalsSignal cascadeCell survivalCardiovascular biologyASK1Signal pathwayKey moleculesNovel therapeutic strategiesPathwayCrucial roleASK3MAPKKKASK2Therapeutic strategiesCardiovascular pathophysiologyBiologyApoptosisMitogenRegulationCurrent reviewCascadeProliferation