2015
AIP1-Mediated Stress Signaling in Atherosclerosis and Arteriosclerosis
Zhang J, Zhou HJ, Ji W, Min W. AIP1-Mediated Stress Signaling in Atherosclerosis and Arteriosclerosis. Current Atherosclerosis Reports 2015, 17: 24. PMID: 25732743, PMCID: PMC5051342, DOI: 10.1007/s11883-015-0503-z.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesHuman genome-wide association studiesApoptosis signal-regulating kinase 1Signal-regulated kinases 1EC-specific deletionEndothelial cellsStress signalingEndoplasmic reticulum stressAIP1 functionsKinase 1Association studiesAIP1Human cardiovascular diseaseVascular endothelial cellsReticulum stressProteinGene variantsMouse modelDAB2IPSignalingInflammatory responseDeletionRegulationStressCells
2010
Chapter 19 Thioredoxin and Redox Signaling in Vasculature—Studies Using Trx2 Endothelium-Specific Transgenic Mice
Min W, Xu L, Zhou H, Huang Q, Zhang H, He Y, Zhe X, Luo Y. Chapter 19 Thioredoxin and Redox Signaling in Vasculature—Studies Using Trx2 Endothelium-Specific Transgenic Mice. Methods In Enzymology 2010, 474: 315-324. PMID: 20609919, DOI: 10.1016/s0076-6879(10)74019-2.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesCellular reactive oxygen speciesMitochondrial antioxidant systemVivo functional assaysTRX2 geneRedox signalingTransgenic miceRedox genesThioredoxin 2Functional analysisHuman diseasesFunctional assaysAntioxidant systemOxygen speciesGenesCritical roleEndothelial cell culturesCell culturesPrimary lineTrx2TransgenesisThioredoxinMitochondriaSignalingSpecies