TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy
Liang X, Zhou H, Ding Y, Li J, Yang C, Luo Y, Li S, Sun G, Liao X, Min W. TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2012, 53: 2157-2169. PMID: 22410554, PMCID: PMC4627509, DOI: 10.1167/iovs.11-9315.Peer-Reviewed Original ResearchConceptsEffects of tetramethylpyrazineVEGF mRNA expressionCell bodiesRetinal neovascularizationAvascular retinaMüller cellsMouse retinaHIF-1αMRNA expressionOxygen-induced retinopathy modelIschemia-induced cell deathHorizontal cell bodiesNeonatal C57BL/6J miceOuter plexiform layerPostnatal day 7Amacrine cell bodiesTUNEL-positive cellsMüller cell bodiesImparts NeuroprotectionNeurovascular recoveryNeurovascular repairControl miceC57BL/6J micePlexiform layerNormal saline