2020
Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study
Petrakis I, Ralevski E, Arias AJ, DeNegre D, Newcomb J, Gianoli M, McCarthy E, Meshberg‐Cohen S, Yoon G. Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study. American Journal On Addictions 2020, 29: 515-524. PMID: 32462773, DOI: 10.1111/ajad.13061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol-Related DisordersAnticonvulsantsCognitive Behavioral TherapyCombined Modality TherapyDiagnosis, Dual (Psychiatry)Double-Blind MethodFeasibility StudiesFemaleHumansMaleMiddle AgedPatient SatisfactionPilot ProjectsStress Disorders, Post-TraumaticTreatment OutcomeVeterans HealthZonisamideConceptsAlcohol use disorderPosttraumatic stress disorderCognitive processing therapyComorbid alcohol use disorderSymptoms of PTSDUse disordersStress disorderPilot studyNonsignificant higher rateDouble-blind fashionReal-world treatmentCurrent alcohol dependenceEvidence-based psychotherapiesHigh rateAdjunctive treatmentPreliminary efficacyTreatment strategiesPsychosocial treatmentsPTSD outcomesZonisamideAlcohol dependencePlaceboLarger studyAlcohol useDisorders
2017
Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity
Ralevski E, Shanabrough M, Newcomb J, Gandelman E, Hayden R, Horvath TL, Petrakis I. Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity. Alcohol And Alcoholism 2017, 53: 52-56. PMID: 29136100, DOI: 10.1093/alcalc/agx082.Peer-Reviewed Original ResearchConceptsAspects of impulsivityTraits of impulsivityHealthy social drinkersSocial drinkersReward sensitivityImpulsivity traitsPersonality measuresPersonality differencesImpulsivityDrugs of abusePersonality characteristicsSubjective effectsDirect relationshipHigh levelsDrinkersFeeding-related peptidesPunishmentFirst studyIndividualsTraitsSecondary analysisParticipantsAbuseRelationshipOriginal studyGhrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol
Ralevski E, Horvath TL, Shanabrough M, Hayden R, Newcomb J, Petrakis I. Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. Alcohol And Alcoholism 2017, 52: 431-438. PMID: 28481974, DOI: 10.1093/alcalc/agx022.Peer-Reviewed Original ResearchConceptsGhrelin levelsDoses of alcoholHealthy social drinkersSubjective effectsTG levelsAlcohol infusionSedative effectsLow doseHigh doseOral alcohol administrationIntravenous alcohol infusionFeeding-related peptidesSocial drinkersAlcohol administrationIntravenous alcoholOral alcoholGhrelinPercent changeInfusionRewarding propertiesBehavioral effectsAlcohol effectsDoseTime pointsSignificant predictors
2016
Effect of Intravenous Ethanol on Capsaicin‐Induced Hyperalgesia in Human Subjects
Arout CA, Perrino AC, Ralevski E, Acampora G, Koretski J, Limoncelli D, Newcomb J, Petrakis IL. Effect of Intravenous Ethanol on Capsaicin‐Induced Hyperalgesia in Human Subjects. Alcohol Clinical And Experimental Research 2016, 40: 1425-1429. PMID: 27218476, PMCID: PMC4930397, DOI: 10.1111/acer.13095.Peer-Reviewed Original ResearchConceptsCapsaicin-induced hyperalgesiaVon Frey techniqueTime pointsArea of hyperalgesiaIntradermal capsaicin injectionExperimental pain paradigmVisual analog scaleAdditional outcome measuresImportant clinical implicationsTest dayETOH infusionHyperalgesia areasIntravenous EtOHAntihyperalgesic effectCentral sensitizationPrimary outcomeCapsaicin injectionChronic painPain processingAnalog scaleBreath alcohol concentrationIntravenous ethanolPain medicineHyperalgesiaOutcome measures
2013
Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp
Kerfoot K, Pittman B, Ralevski E, Limoncelli D, Koretski J, Newcomb J, Arias AJ, Petrakis IL. Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp. Alcohol Clinical And Experimental Research 2013, 37: 2011-2018. PMID: 23895557, PMCID: PMC3971638, DOI: 10.1111/acer.12199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective responsesBiphasic Alcohol Effects ScaleSubjective effectsUse disordersEffects of FHSimilar dose-related effectsTest dayCognitive effectsCognitive functionHigh-dose alcoholMeasure of coordinationSeparate test daysFamily historySubjective measuresHigh-dose EtOHImpairment of coordinationAlcohol challengeAlcohol dependenceEffects ScaleDouble-blind conditionsLow-dose ethanolAlcohol administrationVisual analog scaleIndividuals