2024
Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisorders
2022
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers
Ralevski E, Horvath T, Shanabrough M, Newcomb J, Pisani E, Petrakis I. Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. Alcohol And Alcoholism 2022, 58: 100-106. PMID: 36382470, PMCID: PMC9830489, DOI: 10.1093/alcalc/agac058.Peer-Reviewed Original Research
2017
Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity
Ralevski E, Shanabrough M, Newcomb J, Gandelman E, Hayden R, Horvath TL, Petrakis I. Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity. Alcohol And Alcoholism 2017, 53: 52-56. PMID: 29136100, DOI: 10.1093/alcalc/agx082.Peer-Reviewed Original ResearchConceptsAspects of impulsivityTraits of impulsivityHealthy social drinkersSocial drinkersReward sensitivityImpulsivity traitsPersonality measuresPersonality differencesImpulsivityDrugs of abusePersonality characteristicsSubjective effectsDirect relationshipHigh levelsDrinkersFeeding-related peptidesPunishmentFirst studyIndividualsTraitsSecondary analysisParticipantsAbuseRelationshipOriginal studyGhrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol
Ralevski E, Horvath TL, Shanabrough M, Hayden R, Newcomb J, Petrakis I. Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. Alcohol And Alcoholism 2017, 52: 431-438. PMID: 28481974, DOI: 10.1093/alcalc/agx022.Peer-Reviewed Original ResearchConceptsGhrelin levelsDoses of alcoholHealthy social drinkersSubjective effectsTG levelsAlcohol infusionSedative effectsLow doseHigh doseOral alcohol administrationIntravenous alcohol infusionFeeding-related peptidesSocial drinkersAlcohol administrationIntravenous alcoholOral alcoholGhrelinPercent changeInfusionRewarding propertiesBehavioral effectsAlcohol effectsDoseTime pointsSignificant predictors
2013
Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp
Kerfoot K, Pittman B, Ralevski E, Limoncelli D, Koretski J, Newcomb J, Arias AJ, Petrakis IL. Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp. Alcohol Clinical And Experimental Research 2013, 37: 2011-2018. PMID: 23895557, PMCID: PMC3971638, DOI: 10.1111/acer.12199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective responsesBiphasic Alcohol Effects ScaleSubjective effectsUse disordersEffects of FHSimilar dose-related effectsTest dayCognitive effectsCognitive functionHigh-dose alcoholMeasure of coordinationSeparate test daysFamily historySubjective measuresHigh-dose EtOHImpairment of coordinationAlcohol challengeAlcohol dependenceEffects ScaleDouble-blind conditionsLow-dose ethanolAlcohol administrationVisual analog scaleIndividuals
2012
Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism
Petrakis IL, Kerfoot K, Pittman B, Perrino A, Koretski J, Newcomb J, Limoncelli D, Acampora G, Ralevski E. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. Journal Of Addiction Research & Therapy 2012, 2013 PMID: 24273687, PMCID: PMC3835602, DOI: 10.4172/2155-6105.s7-002.Peer-Reviewed Original ResearchAlcohol use disorderSubjective effectsUse disordersSub-anesthetic dosesAlcohol-related measuresSignificant main effectCognitive effectsAlcohol-like effectsFHN individualsSeparate test daysStimulant effectsYoung adultsCognitionMain effectSubjective responsesAlcohol dependenceTest dayFamily historyImpaired coordinationIndividualsResponse differencesFamily history-negative subjectsDisordersHealthy individualsFHP