2024
Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisorders
2023
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study
Ralevski E, Newcomb J, Pisani E, DeNegre D, Peltier M, Jane J, Yoon G, Petrakis I. Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study. Journal Of Dual Diagnosis 2023, 20: 39-51. PMID: 38147491, PMCID: PMC11214330, DOI: 10.1080/15504263.2023.2294989.Peer-Reviewed Original ResearchAlcohol use disorderStress-induced cravingCognitive performanceNegative affectNeutral scriptsStress disorderPost-traumatic stress disorderComorbid alcohol use disorderTraumatic Stress DisorderMeasures of cravingCurrent alcohol use disorderPositive emotionsTrauma scriptsPhysiological measuresCravingStress-induced symptomsTest sessionsPTSDAnxietyAffectUse disordersLaboratory sessionsCocaine dependenceAlcohol dependenceIndividuals
2020
Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study
Petrakis I, Ralevski E, Arias AJ, DeNegre D, Newcomb J, Gianoli M, McCarthy E, Meshberg‐Cohen S, Yoon G. Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study. American Journal On Addictions 2020, 29: 515-524. PMID: 32462773, DOI: 10.1111/ajad.13061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol-Related DisordersAnticonvulsantsCognitive Behavioral TherapyCombined Modality TherapyDiagnosis, Dual (Psychiatry)Double-Blind MethodFeasibility StudiesFemaleHumansMaleMiddle AgedPatient SatisfactionPilot ProjectsStress Disorders, Post-TraumaticTreatment OutcomeVeterans HealthZonisamideConceptsAlcohol use disorderPosttraumatic stress disorderCognitive processing therapyComorbid alcohol use disorderSymptoms of PTSDUse disordersStress disorderPilot studyNonsignificant higher rateDouble-blind fashionReal-world treatmentCurrent alcohol dependenceEvidence-based psychotherapiesHigh rateAdjunctive treatmentPreliminary efficacyTreatment strategiesPsychosocial treatmentsPTSD outcomesZonisamideAlcohol dependencePlaceboLarger studyAlcohol useDisorders