2022
FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization
Qiu A, Miller A, Dei Zotti F, Santhanakrishnan M, Hendrickson JE, Tredicine M, Stowell SR, Luckey CJ, Zimring JC, Hudson KE. FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Frontiers In Immunology 2022, 13: 972723. PMID: 36189253, PMCID: PMC9519184, DOI: 10.3389/fimmu.2022.972723.Peer-Reviewed Original ResearchConceptsAlloantibody productionRBC alloimmunizationPassive immunizationRBC clearanceSplenic dendritic cell subsetsRed blood cell transfusionSplenic conventional DCsBlood cell transfusionDendritic cell subsetsConventional DCsFc gamma receptorsHumoral alloimmunizationAlloantibody responsesCell transfusionMaternal alloimmunizationCell subsetsFcγR expressionIgG antibodiesHemolytic diseaseBlocking antibodiesAlloimmunizationImmune complexesMouse modelKnockout miceAntibodies
2010
MHC II on transfused murine blood is not required for alloimmunization against MHC I
Gilson C, Cadwell C, Smith N, Hendrickson J, Zimring J. MHC II on transfused murine blood is not required for alloimmunization against MHC I. Vox Sanguinis 2010, 99: 369-374. PMID: 20546207, PMCID: PMC2955847, DOI: 10.1111/j.1423-0410.2010.01351.x.Peer-Reviewed Original ResearchConceptsMHC IMHC-IIBALB/c recipientsMajor histocompatibility complex IMHC-II expressionSubsequent platelet transfusionsHumoral alloimmunizationC recipientsPlatelet transfusionsHumoral responseNull donorsIgG subclassesMHC-II genesMouse modelAlloimmunizationC57BL/6 backgroundMurine bloodIndirect immunofluorescencePlatelet productsBloodRefractory stateTransfusionRecipientsMolecular mechanismsC57BL/6