2009
Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs.
Hendrickson J, Hod E, Spitalnik S, Hillyer C, Zimring J. Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs. Blood 2009, 114: 640. DOI: 10.1182/blood.v114.22.640.640.Peer-Reviewed Original ResearchWhite blood cellsHOD RBCsPost-transfusion survivalCytometric crossmatchingRBC alloimmunizationLeukoreduction filtersHen egg lysozymeRBC antigensFlow cytometryRBC-specific expressionRed blood cell antigensReductionist murine modelHemolytic transfusion reactionsMinority of miceLateral tail veinAntigen hen egg lysozymeBlood cell antigensEffect of leukoreductionResidual white blood cellsPropridium iodideAltered clearanceHLA alloimmunizationSingle transfusionHLA antigensTransfusion reactions
2008
A Novel Model of Autoimmunity to Self Red Blood Cell Antigens
Hendrickson J, Cadwell C, Hillyer C, Zimring J. A Novel Model of Autoimmunity to Self Red Blood Cell Antigens. Blood 2008, 112: 3461. DOI: 10.1182/blood.v112.11.3461.3461.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaB1 B cellsSelf-reactive B cellsReactive B cellsAutoreactive B cellsB cell toleranceB cellsControl micePositive miceB cell maturationLymph nodesBone marrowCell toleranceRBC antigensCell maturationRBC-specific expressionRed blood cell antigensSystemic immune activationHuman blood group antigensAntigen hen egg lysozymeLife-threatening illnessConventional B cellsBlood cell antigensSigns of illnessHemoglobin breakdown productsBerkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice
HendricKson J, Archer D, Perry J, Hillyer C, Zimring J. Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice. Blood 2008, 112: 292. DOI: 10.1182/blood.v112.11.292.292.Peer-Reviewed Original ResearchCo-stimulatory molecule expressionSickle cell diseaseBerkeley miceAntigen presenting cellsCell diseaseSickle cell traitMolecule expressionForeign antigensRBC alloimmunizationBaseline inflammationDendritic cellsPresenting cellsRed blood cell alloimmunizationCell traitIndividual miceELISA 2 weeksRate of alloimmunizationRBC-specific expressionTransfusion of RBCsHuman blood group antigensLevel of illnessAntigen hen egg lysozymeDonor/recipientHigh rateTime of illness