2024
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease
Bini J. The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease. Journal Of Alzheimer's Disease 2024, 99: 113-115. PMID: 38607759, DOI: 10.3233/jad-231463.Peer-Reviewed Original Research
2018
Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet
Rutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC, . Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLOS ONE 2018, 13: e0191909. PMID: 29444171, PMCID: PMC5812615, DOI: 10.1371/journal.pone.0191909.Peer-Reviewed Original ResearchConceptsWestern dietBrain metabolismCognitive functionC57BL/6 miceBarrier transportLow-density lipoprotein receptor-null miceBlood-brain barrier transportLDLR-/- miceReceptor null miceModel of hyperlipidemiaRadial arm water mazeProinflammatory lipid mediatorsIndicator of activationBBB transportInflammatory responseLipid levelsMetabolic assessmentLipid mediatorsWhole mouse brainWater mazeCognitive declineCognitive impairmentMouse brainBrain metabolitesNull mice