2013
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Montalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation. Neuropsychopharmacology 2013, 39: 1469-1478. PMID: 24366052, PMCID: PMC3988551, DOI: 10.1038/npp.2013.346.Peer-Reviewed Original ResearchConceptsC-fos expressionAged miceValproic acidNucleus accumbensPrefrontal cortexYoung miceMS-275HDAC inhibitorsC-Fos expression patternHDAC inhibitor valproic acidAntipsychotic drug actionEffects of haloperidolAge-related decreaseInhibitor valproic acidHistone deacetylase inhibitorsElderly patientsHAL administrationHistone acetylationAntipsychotic drugsAvoidance responseBehavioral disturbancesElderly individualsClinical experienceHaloperidolEpigenetic changes
2012
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease
Dong H, Murphy KM, Meng L, Montalvo-Ortiz J, Zeng Z, Kolber BJ, Zhang S, Muglia LJ, Csernansky JG. Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 28: 579-592. PMID: 22045495, PMCID: PMC3494090, DOI: 10.3233/jad-2011-111328.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceAnimalsAnxietyBody WeightCalcium-Calmodulin-Dependent Protein Kinase Type 2Cognition DisordersConditioning, PsychologicalCorticosteroneCorticotropin-Releasing HormoneDark AdaptationDendritic SpinesDisease Models, AnimalDoxycyclineEnzyme-Linked Immunosorbent AssayExploratory BehaviorFearGene Expression RegulationHumansMiceMice, TransgenicNeuronsPlaque, AmyloidProsencephalonReceptors, Corticotropin-Releasing HormoneSilver StainingTubulinConceptsCorticotrophin-releasing factorTransgenic mouse modelTriple transgenic mouse modelTT miceMouse modelMonths of ageAlzheimer's diseaseExpression of CRFChronic stressHuman amyloid-β protein precursorNovel transgenic mouse modelDendritic spine densityAmyloid-β protein precursorAnxiety-like behaviorAβPP genePyramidal neuronsSpine densityAmyloid depositionAmyloid metabolismCRF expressionFrontal cortexBehavioral deficitsDendritic branchingCognitive declineMice