2022
Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans
Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.Peer-Reviewed Original ResearchConceptsRisk factorsPremature mortalityU.S. veteransPsychosocial variablesNovel epigenetic clockLifetime substance use disorderRisk stratification modelMale U.S. veteransCross-sectional studyU.S. veteran populationWeekly physical exerciseSubstance use disordersMale U.S. military veteransBiological agingU.S. military veteransHealth morbidityModifiable correlatesMortality riskSleep qualityHigh riskGreater oddsUse disordersPhysical exercisePsychosocial factorsVeteran population
2019
Understanding risk and resilience in maltreated children
Kaufman J, Montalvo-Ortiz J, Lee R. Understanding risk and resilience in maltreated children. 2019, 304-323. DOI: 10.1093/oso/9780198793014.003.0021.ChaptersHistory of abuseMaltreated youthRelevant empirical workFunctional brain changesPsychiatric disordersMeta-analytic studyMultiple brain regionsCognitive processesSubstance use disordersMaltreated childrenBrain measuresGenetic factorsPoor treatment responseDistinct psychiatric disordersResiliency StudyNeural plasticityBrain regionsChild abuseChild maltreatmentBrain changesEnrichment experiencesDiverse clinical phenotypesUse disordersPositive supportClinical interventions
2015
RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders
Montalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 171: 81-91. PMID: 26592203, PMCID: PMC4754782, DOI: 10.1002/ajmg.b.32395.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related psychiatric disordersPsychiatric disordersTrauma-related psychiatric disordersAdverse early life experiencesSubstance use disordersGenetic risk factorsKey brain structuresDistinct neural circuitsDistinct psychiatric disordersSubstance use problemsClinical syndromeRisk factorsHigh riskPsychiatric problemsUse disordersAdverse early experiencesTranslational studiesGenome-wide association studiesClinical phenotypeNeural circuitsBrain structuresResearch Domain Criteria frameworkCircuitry developmentEarly life experiencesAnxiety disordersEarly Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates
Varghese SP, Montalvo-Ortiz JL, Csernansky JG, Eiger RI, Herrold AA, Koola MM, Dong H. Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates. Indian Journal Of Psychological Medicine 2015, 37: 36-41. PMID: 25722510, PMCID: PMC4341308, DOI: 10.4103/0253-7176.150816.Peer-Reviewed Original ResearchEarly life stressWithdrawal symptomsMorphine administrationMorphine sensitizationWT miceCRF-OEOpiate withdrawal symptomsDoses of morphineCRF-OE miceEffects of ELSLife stressWild-type miceSubstance use disordersCRF miceRisk factorsImmunohistochemistry studiesNucleus accumbensType miceImmunohistochemistry analysisUse disordersMorphineBehavioral trialsSymptomsMiceElevated levels