Janitza Montalvo-Ortiz, PhD
Assistant Professor of PsychiatryCards
About
Titles
Assistant Professor of Psychiatry
Biography
My research interests include the study of the genetic and epigenetic mechanisms associated with psychiatry disorders. I investigate how trauma-related events increase the vulnerability to develop mental disorders later in life.
Appointments
Psychiatry
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Center for Brain & Mind Health
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Montalvo-Ortiz Lab
- Program in Translational Biomedicine (PTB)
- Psychiatry
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- PhD
- Northwestern University, Neuroscience (2014)
- BA
- University of Puerto Rico, Biology (2009)
Research
Publications
2024
Potential use of epigenetic clocks to understand factors associated with aging at the population level and in public health
Martínez-Magaña J, Hurtado-Soriano J, Montalvo-Ortiz J, Gomez-Verjan J. Potential use of epigenetic clocks to understand factors associated with aging at the population level and in public health. Gaceta Médica De México 2024, 160: 357-359. PMID: 39602607, DOI: 10.24875/gmm.m24000897.Peer-Reviewed Original ResearchPosttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81 PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchMulti-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder
Zillich E, Belschner H, Avetyan D, Andrade-Brito D, Martínez-Magaña J, Frank J, Mechawar N, Turecki G, Cabana-Domínguez J, Fernàndez-Castillo N, Cormand B, Montalvo-Ortiz J, Nöthen M, Hansson A, Rietschel M, Spanagel R, Witt S, Zillich L. Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder. Translational Psychiatry 2024, 14: 428. PMID: 39384764, PMCID: PMC11464785, DOI: 10.1038/s41398-024-03139-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderUse disorderAlternative splicingHuman prefrontal cortexProfiling of DNA methylationBrodmann area 9Differential alternative splicingDeregulated biological processesPostmortem brain tissueMulti-omics approachCocaine intakeMulti-omics studiesPrefrontal cortexBrain alterationsMulti-omics profilingGene expression alterationsArea 9Fatty acid metabolismReceptor-targeting drugsSpliced transcriptsEpigenome-wideDNA methylationNeuronal morphogenesisAS changesDrug repositioning analysisUso potencial a nivel poblacional y en salud pública de los relojes epigenéticos para entender los factores asociados al envejecimiento
Martínez-Magaña J, Hurtado-Soriano J, Montalvo-Ortiz J, Gomez-Verjan J. Uso potencial a nivel poblacional y en salud pública de los relojes epigenéticos para entender los factores asociados al envejecimiento. Gaceta Médica De México 2024, 160: 357-359. DOI: 10.24875/gmm.24000133.Peer-Reviewed Original ResearchT7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION
Garayua A, Nunez D, Nagamatsu S, Giusti-Rodriguez P, Martinez-Gonzalez K, Montalvo-Ortiz J. T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION. European Neuropsychopharmacology 2024, 87: 159. DOI: 10.1016/j.euroneuro.2024.08.317.Peer-Reviewed Original ResearchPost-traumatic stress disorderMajor depressive disorderCOVID-19 related stressorsCOVID-19 stressorsMajor depressive disorder symptomsPost-traumatic stress disorder symptomsAccelerated epigenetic agingRelated stressorsCombined sex analysesSymptoms of major depressive disorderPsychiatric disorder symptomsCOVID-19-related stressorsSex-stratified analysesSelf-report measuresCOVID-related stressorsAdverse mental health outcomesTargeted mental health interventionsSignificant stressorsAt-risk populationsMental health interventionsMental health outcomesConsequences of stressorsAccelerated biological agingEpigenetic ageAt-riskW69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS
Nunez D, Martinez-Magana J, Nagamatsu S, Andrade-Brito D, Hernandez-Amaya L, Montalvo-Ortiz J. W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS. European Neuropsychopharmacology 2024, 87: 138-139. DOI: 10.1016/j.euroneuro.2024.08.278.Peer-Reviewed Original ResearchDorsal anterior cingulate cortexPrefrontal cortex subregionsPrefrontal cortexOrbitofrontal cortexDifferential transcript usagePercent-spliced-inSubgenual prefrontal cortexPrefrontal cortex regionsAnterior cingulate cortexDorsolateral prefrontal cortexDSM-IV criteriaAS eventsTranscript usageSynaptic processesExon skippingDSM-IVSCID-1Cingulate cortexIntron retentionMood disordersPsychiatric disordersSplice siteAlternative splicingCognitive functionNon-psychiatric diagnosesF95. LOCAL ANCESTRY-AWARE META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES FOR ALCOHOL CONSUMPTION IN LATIN AMERICAN POPULATIONS
Martinez-Magana J, Atkinson E, Giusti-Rodriguez P, Santoro M, Wassertheil-Smoller S, Daviglus M, Perreira K, Nicolini H, Pereira A, Belangero S, Moyses-Oliveira M, Tucker K, Ordovas J, Villatoro-Velazquez J, Montalvo-Ortiz J. F95. LOCAL ANCESTRY-AWARE META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES FOR ALCOHOL CONSUMPTION IN LATIN AMERICAN POPULATIONS. European Neuropsychopharmacology 2024, 87: 256. DOI: 10.1016/j.euroneuro.2024.08.506.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study studiesAncestry-specific effectsIntergenic variantAlcohol consumptionAncestry-specific lociNative-American ancestryFrequency of alcohol consumptionAssociated with alcohol consumptionMeta-analysisLocal ancestryAdmixed populationsGWA studiesGenomic backgroundAssociation studiesSLIT3 geneMAGI1 genesGenomics ConsortiumGenetic associationGenesLatin American populationsAfrican ancestryGenetic liabilityUnited StatesAncestryF91. MAPPING THE EFFECTS OF OPIOID USE DISORDER GENETIC ASSOCIATED VARIANTS IN BRAIN PATHWAYS AT A SINGLE CELL LEVEL
Rivera-Hernández M, Martínez-Magaña J, Brennand K, Montalvo-Ortiz J. F91. MAPPING THE EFFECTS OF OPIOID USE DISORDER GENETIC ASSOCIATED VARIANTS IN BRAIN PATHWAYS AT A SINGLE CELL LEVEL. European Neuropsychopharmacology 2024, 87: 254. DOI: 10.1016/j.euroneuro.2024.08.502.Peer-Reviewed Original ResearchOpioid use disorderDopaminergic neuronsReward-related learningOrbital frontal cortexGenetic variantsFunction of dopaminergic neuronsMap genetic variantsGenome-wide studiesCell projection organizationSingle-cell expression profilesCell typesOxytocin signaling pathwayPrefrontal cortexMotivated behaviorFrontal cortexDopaminergic pathwaysUse disorderBrain regionsModulation of chemical synaptic transmissionStriatumSingle-cell RNAseqCell-specific pathwaysBehavioral responsesScRNA-seqStriatum cellsTowards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology
Martínez-Magaña J, Hurtado-Soriano J, Rivero-Segura N, Montalvo-Ortiz J, Garcia-delaTorre P, Becerril-Rojas K, Gomez-Verjan J. Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology. Archives Of Medical Research 2024, 55: 103033. PMID: 38955096, DOI: 10.1016/j.arcmed.2024.103033.Peer-Reviewed Original ResearchImpact of public health interventionsHealth problems associated with agingPublic health interventionsPublic health strategiesEpigenetic clocksEfficacy of interventionsProblems associated with agingBiological agePublic health concernHealth interventionsHealth strategiesAssociated with ageDNA methylation levelsHuman phenomeHealthy agingHealth concernEpigenetic ageMultiple traitsHealthMethylation levelsInterventionAssociationAgeEpidemiological contextHealth spanThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- September 18, 2024
Montalvo-Ortiz Featured on Atlas of Inspiring Hispanic/Latinx Scientists
- December 14, 2023
Montalvo-Ortiz Accepts Pamela Sklar Innovation Award For Latin American Genomics Consortium
- October 17, 2023
Construyendo Comunidad: Inaugural Conference Unites Latine Health Professionals
- September 22, 2023Source: Psychological Medicine
In Study of Veterans, Positive Personality Traits Moderate Persistent High Alcohol Consumption