2001
Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat
Lee J, Azzaroli F, Wang L, Soroka C, Gigliozzi A, Setchell K, Kramer W, Boyer J. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 2001, 121: 1473-1484. PMID: 11729126, DOI: 10.1053/gast.2001.29608.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBile Acids and SaltsCarrier ProteinsCholestasisCommon Bile DuctFluorescent Antibody TechniqueKidneyLigationLiverMaleMicrovilliMitochondrial ProteinsOrganic Anion Transporters, Sodium-DependentRatsRats, Sprague-DawleyRibosomal ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsSymportersConceptsBile salt excretionCommon bile duct ligationBile salt transportersBile duct ligationSalt excretionObstructive cholestasisSalt transportersDuct ligationCommon bile duct obstructionKidney 14 daysBile duct obstructionBile salt transport proteinsSerum bile saltsBrush border membrane vesiclesProtein 2 expressionBile salt transportSodium-dependent uptakeExtrahepatic pathwaysLiver injuryDuct obstructionTissue immunofluorescenceBorder membrane vesiclesTransporter messenger RNAExtrahepatic tissuesTotal liver
2000
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
Lee J, Trauner M, Soroka C, Stieger B, Meier P, Boyer J. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000, 118: 163-172. PMID: 10611165, DOI: 10.1016/s0016-5085(00)70425-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBile Acids and SaltsBile DuctsCarrier ProteinsCholestasisChronic DiseaseDrug Resistance, MultipleEthinyl EstradiolLigationLipopolysaccharidesMembrane ProteinsMultidrug Resistance-Associated ProteinsOrganic Anion Transporters, Sodium-DependentRatsRats, Sprague-DawleyRNA, MessengerSymportersConceptsBile salt export pumpBile duct ligationCommon bile duct ligationBile salt excretionDuct ligationExport pump
1977
Evaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology
WOOD R, BAKER A, HALL A, BOYER J, MOOSSA A. Evaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology. Annals Of Surgery 1977, 185: 349-355. PMID: 402891, PMCID: PMC1396621, DOI: 10.1097/00000658-197703000-00017.Peer-Reviewed Original ResearchConceptsBile flowSecretory physiologyMonkey modelBile salt secretion rateFinal infusion rateBile salt excretionBile salt outputHigher bile flowNew monkey modelSalt secretion rateBicarbonate outputPostoperative managementInfusion rateTaurocholate infusionSalt outputSalt excretionSecretion rateLong-term studiesRandom orderPeriod of monthsSecretinClearance
1970
The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.Peer-Reviewed Original ResearchConceptsBile salt excretionBSP TmBile flowBile productionBiliary concentrationHepatic metabolismBile saltsBiliary bile salt excretionSalt excretionSulfobromophthalein sodiumSodium taurocholateMug/minSodium taurocholate infusionBile salt infusionBSP transportCholeretic propertiesSaline infusionTaurocholate infusionIndependent factorsConstant infusionHepatic uptakeMumoles/hrInfusionMul/minPeak levels