2023
Prognosis and risk of suicide after cancer diagnosis
Kinslow C, Kumar P, Olfson M, Wall M, Petridis P, Horowitz D, Wang T, Kachnic L, Cheng S, Prigerson H, Yu J, Neugut A. Prognosis and risk of suicide after cancer diagnosis. Cancer 2023, 130: 588-596. PMID: 38018695, DOI: 10.1002/cncr.35118.Peer-Reviewed Original ResearchConceptsRisk of suicideCancer diagnosisSuicide riskCancer sitesMonths of diagnosisRelative risk of suicideSuicide deathsBaseline suicide riskSuicide ratesNewly diagnosed cancerYears of follow-upImpact of prognosisExistential distressAssociated with suicide riskMortality ratioWeighted linear regression modelImpending deathLinear regression modelsUS populationRelative riskGeneral populationBaseline riskAssociated with overall prognosisEnd Results databaseOverall survival rate
2022
Association between social connectedness and stress or anxiety among older cancer survivors during the 2020–2021 winter surge of the COVID-19 pandemic
Poghosyan H, Margaryan Y, Jeon S, Edelman EJ, Yu JB. Association between social connectedness and stress or anxiety among older cancer survivors during the 2020–2021 winter surge of the COVID-19 pandemic. Journal Of Geriatric Oncology 2022, 14: 101390. PMID: 36274031, PMCID: PMC9554341, DOI: 10.1016/j.jgo.2022.10.005.Peer-Reviewed Original ResearchFostering Transdisciplinary Collaborations in Cancer Health Economics Research
Yu J. Fostering Transdisciplinary Collaborations in Cancer Health Economics Research. JNCI Monographs 2022, 2022: 85-88. PMID: 35788381, DOI: 10.1093/jncimonographs/lgac001.Peer-Reviewed Original ResearchConceptsHealth economics researchCancer health economics researchEconomic researchHealth economicsHealth-care providersHealth-care decisionsComprehensive research questionsTransdisciplinary collaborationPotential facilitatorsParticipants' discussionsMultifaceted determinantsEconomic theoryEffective collaborationHealthEmpirical techniquesDomains of knowledgeEconomicsCollaborationCancerPanelResearch questionsProvidersParticipantsFacilitationQuestionsHealth Economics Research in Cancer Treatment: Current Challenges and Future Directions
Yu J, Schrag D, Yabroff K. Health Economics Research in Cancer Treatment: Current Challenges and Future Directions. JNCI Monographs 2022, 2022: 51-56. PMID: 35788370, DOI: 10.1093/jncimonographs/lgac009.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareEconomics, MedicalHumansNeoplasmsProspective StudiesResearch PersonnelConceptsHealth economics researchMeasures of social determinants of healthCancer health economics researchNational Cancer Institute's Division of Cancer Control and Population SciencesSocial determinants of healthCost of cancer careDivision of Cancer Control and Population SciencesDeterminants of healthHealth-care systemStudies of cancer treatmentCancer treatmentCancer careIntegration of economic analysisInsurance typeHealth economistsPopulation scienceProspective economic studyHealthArea of focusWorkgroupStandard evaluationEconomic researchCancerCareClinical trials
2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Nationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation
Lee V, Jairam V, Yu JB, Park HS. Nationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation. Scientific Reports 2020, 10: 10084. PMID: 32572113, PMCID: PMC7308286, DOI: 10.1038/s41598-020-67316-8.Peer-Reviewed Original ResearchConceptsBrain metastasesLong-term anticoagulationIntracerebral hemorrhageKidney cancerHigh riskUtilization Project Nationwide Inpatient SampleDiagnosis of ICHHospital-related characteristicsRisks of anticoagulationPrimary cancer diagnosisMultivariable logistic regressionNationwide Inpatient SampleLonger lengthDiagnosis of melanomaMann-Whitney UHemorrhagic strokeNeurologic dysfunctionConcurrent diagnosisSignificant morbiditySecondary diagnosisInpatient SampleBaseline differencesDecreased qualityAnticoagulationHealthcare costsDid quality of life for older cancer survivors improve with the turn of the century in the United States?
Mahal AR, Cramer LD, Wang EH, Wang S, Davidoff AJ, Gross CP, Yu JB. Did quality of life for older cancer survivors improve with the turn of the century in the United States? Journal Of Geriatric Oncology 2020, 12: 102-105. PMID: 32535014, DOI: 10.1016/j.jgo.2020.05.010.Peer-Reviewed Original ResearchConceptsPhysical component summaryMental component summary scoresComponent summary scoresHealth utilityOlder patientsComponent summaryCancer survivorsLung cancerSummary scoresEarly era patientsLung cancer survivorsHealth-related qualityOlder cancer survivorsPopulation-based registryMedicare Advantage patientsLater eraQuality of lifeERA patientsAdvantage patientsMean agePatientsLongitudinal patientSimilar outcomesPropensity scoreCancerDefining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document
Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward W. Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document. Radiotherapy And Oncology 2020, 148: 157-166. PMID: 32388150, DOI: 10.1016/j.radonc.2020.04.003.Peer-Reviewed Original ResearchConceptsMetastasis-directed radiotherapyDefinition of oligometastatic diseaseOligometastatic diseaseMetastatic sitesAbsence of clinical dataMetachronous oligometastatic diseaseRadiation oncology perspectiveDisease-free intervalSingle-centre seriesContext of radiotherapyPatient inclusion criteriaProgression-freeMetastatic locationsCurative intentMetastatic lesionsOverall survivalPrimary tumorSystemic therapyOncological perspectiveQuality-of-lifeClinical dataRadiotherapyLocal controlConsensus documentInclusion criteriaProton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use?
Park HS, Yu JB. Proton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use? JAMA Oncology 2020, 6: 246-247. PMID: 31876903, DOI: 10.1001/jamaoncol.2019.4875.Peer-Reviewed Original Research
2019
Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care
Mahal A, Chavez J, Yang D, Kim D, Cole A, Hu J, Trinh Q, Yu J, Nguyen P, Mahal B. Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care. American Journal Of Clinical Oncology 2019, 43: 163-167. PMID: 31904711, DOI: 10.1097/coc.0000000000000588.Peer-Reviewed Original ResearchConceptsAffordable Care ActAffordable Care Act implementationMedicaid expansionUninsured rateCare ActInsurance coverageInsurance coverage gapsMultivariate logistic regressionCoverage gapSocioeconomic disparitiesCare objectivesSociodemographic disparitiesRacial disparitiesLow-incomeNonelderly adultsLogistic regressionMedicaidBlack patientsDisparitiesEarly impactInsurancePotential benefitsPatientsCancerAffordabilityEmergency Department Visits for Opioid Overdoses Among Patients With Cancer
Jairam V, Yang DX, Yu JB, Park HS. Emergency Department Visits for Opioid Overdoses Among Patients With Cancer. Journal Of The National Cancer Institute 2019, 112: 938-943. PMID: 31845985, PMCID: PMC7492769, DOI: 10.1093/jnci/djz233.Peer-Reviewed Original ResearchConceptsOpioid-related ED visitsED visitsEmergency departmentOpioid overdoseComorbid diagnosesUtilization Project Nationwide Emergency Department SampleMultivariable logistic regression analysisNationwide Emergency Department SampleHigh opioid useOpioid-related visitsPrimary disease siteEmergency department visitsEmergency Department SampleLogistic regression analysisSubstance use disordersOpioid useDepartment visitsChronic painMultiple myelomaNeck cancerPrimary diagnosisRisk factorsPatient visitsBaseline differencesOpioid overdoses
2016
Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop
Smith G, Ganz P, Bekelman J, Chmura S, Dignam J, Efstathiou J, Jagsi R, Johnstone P, Steinberg M, Williams S, Yu J, Zietman A, Weichselbaum R, Shih Y. Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop. International Journal Of Radiation Oncology • Biology • Physics 2016, 97: 450-461. PMID: 28011046, PMCID: PMC6044722, DOI: 10.1016/j.ijrobp.2016.10.042.Peer-Reviewed Original ResearchMeSH KeywordsCosts and Cost AnalysisDecision MakingDiffusion of InnovationHumansNational Academies of Science, Engineering, and Medicine, U.S., Health and Medicine DivisionNeoplasmsProgram EvaluationProton TherapyRadiation OncologyRadiotherapyRadiotherapy, Intensity-ModulatedResearch PersonnelTechnology, RadiologicUnited StatesConceptsRadiation oncology communityRadiation oncology treatmentsRadiation oncologyAdvanced radiation technologiesOncology communityOncological treatmentNational Cancer Policy Forum of the National Academies of SciencesNational Cancer Policy ForumPractice of radiation oncologyRadiation oncology practiceProspective registry dataCancer care decisionsGeneration of scientific evidenceRadiation therapyScientific evidenceEvidence-based effortsComparative effectiveness dataCancer careClinical effectsCare decisionsQuality benchmark dataDe-adoptionRegistry dataThe National Academy of SciencesOncology practiceAttitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO)
Wei R, Mattes M, Yu J, Thrasher A, Shu H, Paganetti H, De Los Santos J, Koontz B, Abraham C, Balboni T. Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO). Practical Radiation Oncology 2016, 7: 113-119. PMID: 28274395, PMCID: PMC5538013, DOI: 10.1016/j.prro.2016.08.017.Peer-Reviewed Original ResearchConceptsAmerican Society for Radiation OncologyRadiation oncologistsPracticing radiation oncologistsInitiate advance care planningLack of clinical timeCare planning discussionsAdvance care planningDiscussion of prognosisRadiation oncologyMedical education effortsRadiation Oncology membersSupportive careCare planningManaging depressionPsychosocial distressPerceived barriersUnited StatesPlanning discussionsManaging painPractice membersMedical educationClinical timeResidency programsResidency trainingAdvanced cancer
2015
US radiation oncology practice patterns for posttreatment survivor care
Koontz B, Benda R, De Los Santos J, Hoffman K, Huq M, Morrell R, Sims A, Stevens S, Yu J, Chen R. US radiation oncology practice patterns for posttreatment survivor care. Practical Radiation Oncology 2015, 6: 50-56. PMID: 26603597, DOI: 10.1016/j.prro.2015.10.002.Peer-Reviewed Original ResearchConceptsSurvivorship care plansCare planningImplementation of survivorship care plansCare of cancer patientsElectronic medical record systemPrimary care providersPhase of careMedical record systemFollow-upRadiation Oncology membersSurvivorship careEligible providersCancer survivorsCare providersNutrition servicesKey barriersCurative intent patientsCare patternsLength of follow-upElectronic surveyImprove communicationOncology practiceCareProfessional guidelinesPractice patternsTrends in Adjuvant and Neoadjuvant Radiotherapy for Cancer Treatment From 1973 to 2011
Le Bui D, Yu J. Trends in Adjuvant and Neoadjuvant Radiotherapy for Cancer Treatment From 1973 to 2011. The Cancer Journal 2015, 21: 147-149. PMID: 26049692, DOI: 10.1097/ppo.0000000000000114.Peer-Reviewed Original ResearchConceptsNeoadjuvant radiation therapyRadiation therapyThyroid cancerCervical cancerKidney cancerRadiation therapy useEnd Results databaseCancer-directed surgeryPercentage of patientsCoordinated careNeoadjuvant radiotherapyOral cavity/pharynxOvarian cancerProstate cancerResults databaseUterine cancerGenitourinary cancersOral cavityPancreatic cancerBladder cancerTherapy useMultidisciplinary clinical teamBreast cancerDisease sitesTherapy usageIn Reply to Rusthoven and Kavanagh
Jagsi R, Bekelman J, Chen A, Chen R, Hoffman K, Shih Y, Smith B, Yu J. In Reply to Rusthoven and Kavanagh. International Journal Of Radiation Oncology • Biology • Physics 2015, 91: 680-681. PMID: 25680609, DOI: 10.1016/j.ijrobp.2014.11.005.Peer-Reviewed Original Research
2014
Considerations for Observational Research Using Large Data Sets in Radiation Oncology
Jagsi R, Bekelman J, Chen A, Chen R, Hoffman K, Shih Y, Smith B, Yu J. Considerations for Observational Research Using Large Data Sets in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 11-24. PMID: 25195986, PMCID: PMC4159773, DOI: 10.1016/j.ijrobp.2014.05.013.Peer-Reviewed Original ResearchMeSH KeywordsChecklistComparative Effectiveness ResearchDatabases, FactualDiffusion of InnovationHealth Care CostsHealth Services ResearchHealth SurveysInsurance Claim ReviewMedicareNeoplasmsNomogramsObservational Studies as TopicProfessional PracticePropensity ScorePublication BiasRadiation OncologyRare DiseasesRegistriesResearch DesignSEER ProgramUnited StatesConceptsRadiation oncology communityRadiation oncologyObservational researchHealth services researchObservational studyWell-designed observational studiesOncology communityField of radiation oncologyHealth careServices researchEvaluate causalityObservational analysisData sourcesInternational Journal of Radiation OncologyMethodological expertiseRadiation oncology researchEvaluate evidenceRecognition of limitationsOncologyClinical trialsPotential data sourcesResearch questionsOncology researchHealthMethodological considerations