2021
Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma
Fisk JN, Mahal AR, Dornburg A, Gaffney SG, Aneja S, Contessa JN, Rimm D, Yu JB, Townsend JP. Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma. Cancer Letters 2021, 526: 346-351. PMID: 34780851, PMCID: PMC8702484, DOI: 10.1016/j.canlet.2021.11.011.Peer-Reviewed Original ResearchConceptsMutational processesSingle ancestral lineageAncestral lineageProgression of cancerMetastatic lineagesPhylogenetic analysisGenetic resistanceEvolutionary processesExogenous mutational processesCancer evolutionConsolidative therapyMutational signature analysisEGFR-positive non-small cell lung cancerNon-small cell lung cancerKey eventsLineagesCell populationsTherapeutic resistanceLocal consolidative therapyClinical time courseCell lung cancerDisease etiologyTherapeutic decision makingCisplatin therapyLung cancerPost-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques
Jairam V, Pasha S, Soulos PR, Gross CP, Yu JB, Park HS, Decker RH. Post-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques. Lung Cancer 2021, 161: 171-179. PMID: 34607209, DOI: 10.1016/j.lungcan.2021.09.010.Peer-Reviewed Original ResearchConceptsPost-operative radiation therapyNon-small cell lung cancerCell lung cancerRadiation therapyPropensity-score matchingLA-NSCLCCardiac toxicityLung cancerAdvanced non-small cell lung cancerClinical risk factorsProportion of patientsMultivariable logistic regressionPrior treatment historyPredictors of receiptUse of IMRTConformal radiation therapyLong-term toxicityChi-squared testRadiation therapy techniquesRadiotherapy treatment techniquesUpfront surgeryElderly patientsTreatment toxicityMean ageMedicare databaseNational Quality Measure Compliance for Palliative Bone Radiation Among Patients With Metastatic Non-Small Cell Lung Cancer.
Grant S, Smith B, Colbert L, Nguyen Q, Yu J, Lin S, Chen A. National Quality Measure Compliance for Palliative Bone Radiation Among Patients With Metastatic Non-Small Cell Lung Cancer. Journal Of The National Comprehensive Cancer Network 2021, 19: 1-6. PMID: 34044365, DOI: 10.6004/jnccn.2020.7688.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerMetastatic non-small cell lung cancerTreatment courseLung cancerBone metastasesSite of metastatic diseaseNational Cancer DatabaseYear of diagnosisNational Quality ForumMetastatic diseaseRadiation therapyPalliative radiationCancer DatabaseBone radiationTreatment characteristicsMultivariate analysisTreatment scheduleRate of complianceRecommended scheduleBony sitesPatientsShort courseCancerAcademic facilitiesAdoption of consolidative durvalumab among patients with locally advanced non-small cell lung cancer.
Jairam V, Pasha S, Soulos P, Goldberg S, Yu J, Decker R, Gross C, Park H. Adoption of consolidative durvalumab among patients with locally advanced non-small cell lung cancer. Journal Of Clinical Oncology 2021, 39: e20550-e20550. DOI: 10.1200/jco.2021.39.15_suppl.e20550.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerTumor characteristicsLung cancerFDA approvalConsolidative durvalumabPatient characteristicsUnresectable stage III non-small cell lung cancerStage III non-small cell lung cancerAdvanced non-small cell lung cancerFirst-line platinum-doublet chemotherapyStudy periodFlatiron Health databasePlatinum-doublet chemotherapyGuideline-concordant carePD-L1 statusMultivariable logistic regressionCochran-Armitage testDe-identified databaseChi-square testDefinitive chemoradiationDoublet chemotherapyEligible patientsPACIFIC trialSurgery detailsPrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Post-Operative Radiation Therapy for Non-Small Cell Lung Cancer: A Comparison of Radiation Therapy Techniques
Jairam V, Pasha S, Soulos P, Gross C, Yu J, Park H, Decker R. Post-Operative Radiation Therapy for Non-Small Cell Lung Cancer: A Comparison of Radiation Therapy Techniques. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e130. DOI: 10.1016/j.ijrobp.2020.07.1276.Peer-Reviewed Original ResearchNon-small cell lung cancerPost-operative radiation therapy
2016
Ceritinib enables stereotactic radiosurgery to a previously untreatable symptomatic brain metastasis in a patient with ALK rearranged non-small cell lung cancer
Qian J, Yu J, Gettinger S, Chiang V. Ceritinib enables stereotactic radiosurgery to a previously untreatable symptomatic brain metastasis in a patient with ALK rearranged non-small cell lung cancer. Cancer Treatment And Research Communications 2016, 6: 17-19. DOI: 10.1016/j.ctrc.2016.02.002.Peer-Reviewed Original ResearchNon-small cell lung cancerAnaplastic lymphoma kinaseWhole-brain radiation therapySymptomatic brain metastasesBrain radiation therapyCell lung cancerBrain metastasesStereotactic radiosurgerySystemic therapyLung cancerRadiation therapyActive small-molecule tyrosine kinase inhibitorLarge symptomatic brain metastasisNext-generation ALK inhibitorsSmall molecule tyrosine kinase inhibitorsYear old Caucasian femaleMolecule tyrosine kinase inhibitorsGeneration ALK inhibitorsALK inhibitor crizotinibOld Caucasian femaleKey driver mutationsTyrosine kinase inhibitorsLocal therapyInhibitor crizotinibALK inhibitors
2015
Survival Comparison of 3 Versus 4-5 Fractions for Stereotactic Body Radiation Therapy in Stage I Non-Small Cell Lung Cancer
Park H, Corso C, Rutter C, Kim A, Yu J, Husain Z, Decker R. Survival Comparison of 3 Versus 4-5 Fractions for Stereotactic Body Radiation Therapy in Stage I Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: s100. DOI: 10.1016/j.ijrobp.2015.07.240.Peer-Reviewed Original ResearchHigher Facility Case Volume of Stereotactic Body Radiation Therapy Is Associated With Improved Overall Survival in Clinical Stage I Non-Small Cell Lung Cancer
Park H, Wang E, Corso C, Rutter C, Wilson L, Kim A, Gross C, Yu J, Decker R. Higher Facility Case Volume of Stereotactic Body Radiation Therapy Is Associated With Improved Overall Survival in Clinical Stage I Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: s186-s187. DOI: 10.1016/j.ijrobp.2015.07.447.Peer-Reviewed Original ResearchPostoperative Radiation Therapy Is Associated With Improved Overall Survival in Incompletely Resected Stage II and III Non-Small Cell Lung Cancer
Wang E, Corso C, Rutter C, Park H, Chen A, Kim A, Wilson L, Decker R, Yu J. Postoperative Radiation Therapy Is Associated With Improved Overall Survival in Incompletely Resected Stage II and III Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e388-e389. DOI: 10.1016/j.ijrobp.2015.07.1538.Peer-Reviewed Original ResearchAssociation Between Radiation Dose and Outcomes With Postoperative Radiation Therapy for N0-N1 Non-Small Cell Lung Cancer
Wang E, Corso C, Park H, Chen A, Kim A, Wilson L, Decker R, Yu J. Association Between Radiation Dose and Outcomes With Postoperative Radiation Therapy for N0-N1 Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e387-e388. DOI: 10.1016/j.ijrobp.2015.07.1536.Peer-Reviewed Original Research
2014
Predictors of 30-Day Mortality Following Resection of Early-Stage NSCLC: An Analysis of the National Cancer Data Base Early-Stage Non-Small Cell Lung Cancer
Husain Z, Kim A, Yu J, Decker R, Corso C. Predictors of 30-Day Mortality Following Resection of Early-Stage NSCLC: An Analysis of the National Cancer Data Base Early-Stage Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s15. DOI: 10.1016/j.ijrobp.2014.08.160.Peer-Reviewed Original ResearchComparative Effectiveness of Stereotactic Body Radiation Therapy Versus Surgery for Stage I Non-small Cell Lung Cancer
Yu J, Soulos P, Cramer L, Decker R, Kim A, Gross C. Comparative Effectiveness of Stereotactic Body Radiation Therapy Versus Surgery for Stage I Non-small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s138. DOI: 10.1016/j.ijrobp.2014.05.596.Peer-Reviewed Original ResearchDiffusion of stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) in the Medicare population, 2007-2009.
Yu J, Soulos P, Cramer L, Decker R, Kim A, Gross C. Diffusion of stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) in the Medicare population, 2007-2009. Journal Of Clinical Oncology 2014, 32: 7575-7575. DOI: 10.1200/jco.2014.32.15_suppl.7575.Peer-Reviewed Original Research
2013
Impact of Preoperative Radiation on Survival of Patients With Node Negative, Very Large Non-small Cell Lung Cancers (T3N0) Treated With Anatomic Resection
Moreno A, Morgensztern D, Yu J, Boffa D, Decker R, Detterbeck F, Kim A. Impact of Preoperative Radiation on Survival of Patients With Node Negative, Very Large Non-small Cell Lung Cancers (T3N0) Treated With Anatomic Resection. Journal Of Surgical Research 2013, 179: 283. DOI: 10.1016/j.jss.2012.10.554.Peer-Reviewed Original Research
2011
Prophylactic Cranial Irradiation for High-Risk Patients with Locally Advanced Non-small Cell Lung Cancer
Park H, Decker R, Wilson L, Yu J. Prophylactic Cranial Irradiation for High-Risk Patients with Locally Advanced Non-small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s627. DOI: 10.1016/j.ijrobp.2011.06.1866.Peer-Reviewed Original Research