2021
Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy
Kang YJ, Clement EM, Park IH, Greenfield LJ, Smith BN, Lee SH. Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy. Experimental Neurology 2021, 342: 113724. PMID: 33915166, PMCID: PMC8192495, DOI: 10.1016/j.expneurol.2021.113724.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyIntrahippocampal kainate mouse modelVentral CA1 regionEpileptic miceCA1 pyramidal cellsSclerotic hippocampusPyramidal cellsSham controlsSpontaneous seizuresLobe epilepsyCA1 regionMouse modelFrequency of IPSCsNetwork oscillationsRecurrent spontaneous seizuresNumber of boutonsHippocampal theta oscillationsIpsilateral hippocampusElectrical recordingsVentral hippocampusCA1 layerGABAergic interneuronsStratum pyramidaleDorsal hippocampusBehavioral comorbidities
2014
In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease
Jeon I, Choi C, Lee N, Im W, Kim M, Oh SH, Park IH, Kim HS, Song J. In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease. International Journal Of Stem Cells 2014, 7: 43-47. PMID: 24921027, PMCID: PMC4049731, DOI: 10.15283/ijsc.2014.7.1.43.Peer-Reviewed Original ResearchHuntington's diseaseHD pathologyNeural precursorsAvailable therapeutic optionsHD mouse modelsYAC128 transgenic miceSignificant behavioral improvementCAG repeatsVivo roleYAC128 modelGrafted miceTherapeutic optionsGrafted cellsPatient-derived iPSCsMouse modelTransgenic miceBehavioral improvementDiseaseNovel therapeuticsMiceCell linesPluripotent stem cell linePathologyStem cellsNeurodegenerative genetic disease
2012
Humanized murine model for HBV and HCV using human induced pluripotent stem cells
Zhou XL, Sullivan GJ, Sun P, Park IH. Humanized murine model for HBV and HCV using human induced pluripotent stem cells. Archives Of Pharmacal Research 2012, 35: 261-269. PMID: 22370780, PMCID: PMC3731984, DOI: 10.1007/s12272-012-0206-8.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusMouse modelHepatocellular carcinomaHuman hepatocytesPathogenesis of HBVVivo transgenic mouse modelAcute asymptomatic infectionsStem cellsHumanized murine modelHumanized mouse modelHuman HCC cell linesNovel mouse modelTransgenic mouse modelPluripotent stem cellsHCC cell linesHuman primary hepatocytesPrimary human hepatocytesAsymptomatic infectionC virusChronic infectionB virusSusceptibility of hepatocytesImmunodeficient miceMurine model
2011
Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells
MacLean G, Menne T, Park I, Daley G, Orkin S. Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells. Blood 2011, 118: 921. DOI: 10.1182/blood.v118.21.921.921.Peer-Reviewed Original ResearchTrisomy 21Trisomic cellsFetal liverAdvisory CommitteeGATA1 mutationsPre-leukemic conditionAcute myeloid leukemiaTransient myeloproliferative disorderTrisomy 21 resultsCell linesDisomic controlsSomatic mutationsCFU-M coloniesColony forming assaysMultilineage hematopoietic progenitor cellsQuantitative RT-PCRHematopoietic progenitor cellsIL-6Myeloid leukemiaMouse modelMyeloproliferative disordersMegakaryoblastic leukemiaProgenitor populationsMyeloid progenitor populationsCD31/CD34
2009
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009, 459: 1126-1130. PMID: 19458618, PMCID: PMC2724004, DOI: 10.1038/nature08062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcineurinCalcium-Binding ProteinsCatecholsCells, CulturedDisease Models, AnimalDNA-Binding ProteinsDown SyndromeEndothelial CellsGene DosageHumansInositolIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicMuscle ProteinsProtein Serine-Threonine KinasesProtein-Tyrosine Kinases