2020
Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder
Sankar A, Purves K, Colic L, Lippard ETC, Millard H, Fan S, Spencer L, Wang F, Pittman B, Constable RT, Gross JJ, Blumberg HP. Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder. Bipolar Disorders 2020, 23: 152-164. PMID: 32521570, PMCID: PMC7790437, DOI: 10.1111/bdi.12954.Peer-Reviewed Original ResearchConceptsExplicit emotion regulationEmotion regulationBrain responsesMood statesDorsal anterior cingulate cortexEmotion regulation difficultiesHappy facial stimuliFrontal cortex functioningDorsal frontal regionsBipolar disorderAcute mood symptomsAnterior cingulate cortexFunctional MRI dataMajor suicide risk factorsNegative affective symptomsEuthymic mood stateRegional brain responsesFacial stimuliRegulation difficultiesFrontal engagementMOFC responseNegative emotionsLoss of motivationDiminished motivationEuthymic individuals
2015
Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment
Millard HY, Wilson BA, Noordsy DL. Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment. The Journal Of The American Board Of Family Medicine 2015, 28: 154-158. PMID: 25567837, DOI: 10.3122/jabfm.2015.01.140105.Peer-Reviewed Educational MaterialsConceptsLow-dose quetiapineCase reportManic symptomsLow dosesDrug-naïve patientsD2 receptor antagonismQuality of lifePossible undertreatmentAcute maniaReceptor blockadeAtypical antipsychoticsBipolar depressionReceptor antagonismPsychotic featuresLifetime prevalenceIrritable moodBipolar disorderMental illnessQuetiapineDopamine concentrationsManiaPotential inductionSymptomsWorseningDoses