2022
RNA methylation in immune cells
Chen Y, Oh M, Flavell R, Li H. RNA methylation in immune cells. Advances In Immunology 2022, 155: 39-94. PMID: 36357012, DOI: 10.1016/bs.ai.2022.08.002.Peer-Reviewed Original ResearchDENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications 2022, 13: 2059. PMID: 35440133, PMCID: PMC9018773, DOI: 10.1038/s41467-022-29754-y.Peer-Reviewed Original ResearchConceptsPD-L1 expressionTumor immune evasionImmune evasionReduced PD-L1 expressionDeath ligand 1Tumor-killing activityT cellsTherapeutic targetTumor growthCancer cellsCRISPR/Cas9 screeningLigand 1Cell homeostasisKinase 2ExpressionEvasionCD8ImmunotherapyCellsIFNγDysfunctionRBP dysfunctionTumorsCancer
2021
Multiple Functions of RNA Methylation in T Cells: A Review
Chao Y, Li H, Zhou J. Multiple Functions of RNA Methylation in T Cells: A Review. Frontiers In Immunology 2021, 12: 627455. PMID: 33912158, PMCID: PMC8071866, DOI: 10.3389/fimmu.2021.627455.Peer-Reviewed Original ResearchConceptsRNA methylationRNA modificationsMessenger RNAFate determinationEpigenetic regulationEpigenetic modificationsNoncoding RNAsCell homeostasisUbiquitous mechanismMethylationBiological significanceT cell homeostasisMultiple functionsCell proliferationEssential rolePotential therapeutic strategyRecent findingsRNAImmune responseBiological activityPathological statesT cellsCellsTherapeutic strategiesViral infectionCross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer
Chen H, Yao J, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y, Li HB. Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer. Molecular Cancer 2021, 20: 29. PMID: 33557837, PMCID: PMC7869236, DOI: 10.1186/s12943-021-01322-w.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorColorectal NeoplasmsCombined Modality TherapyComputational BiologyDisease ManagementDisease SusceptibilityEpithelial-Mesenchymal TransitionGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymphocytes, Tumor-InfiltratingPharmacogeneticsPrognosisProportional Hazards ModelsRNA Processing, Post-TranscriptionalTranscription, GeneticTranscriptomeTumor MicroenvironmentConceptsColorectal cancerConsensus molecular subtypesTumor microenvironmentRNA modification patternsTME cell-infiltrating characteristicsWorse patient overall survivalDevelopment of CRCInhibitory immune cellsPD-L1 blockadeEfficacy of immunotherapyCharacteristics of TMEPatients' overall survivalPotential clinical utilityTherapeutic liabilityOverall survivalClinical featuresClinical benefitPatient survivalImmune cellsM2 macrophagesCRC samplesImmune responseMolecular subtypesClinical utilitySurvival advantageThe RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells
Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2017432118. PMID: 33483420, PMCID: PMC7848544, DOI: 10.1073/pnas.2017432118.Peer-Reviewed Original ResearchConceptsRNA helicasesEssential biological processesPaneth cellsRNA helicase DHX15Antimicrobial protein expressionCell-specific functionsViral RNA sensorsRNA splicingHelicasesUlcerative colitis patientsCell-specific depletionDHX15Complete knockoutKey regulatorBiological processesIntestinal epithelial cellsLethality of miceVivo roleEnteric bacteriaRNA sensorsDextran sodiumColitis patientsLack of evidenceAntimicrobial responsesIntestinal inflammation
2020
A special collection of reviews on frontiers in immunology
Xu C, Li HB, Flavell RA. A special collection of reviews on frontiers in immunology. Cell Research 2020, 30: 827-828. PMID: 32859992, PMCID: PMC7454546, DOI: 10.1038/s41422-020-00403-7.Peer-Reviewed Original Research
2018
RNA m6A modification and its function in diseases
Tong J, Flavell RA, Li HB. RNA m6A modification and its function in diseases. Frontiers Of Medicine 2018, 12: 481-489. PMID: 30097961, DOI: 10.1007/s11684-018-0654-8.Peer-Reviewed Original ResearchConceptsM6A modificationPost-transcriptional RNA modificationsRegulation of m6ACore catalytic componentFunction of m6ARNA m6A modificationRNA metabolismRegulatory networksRNA modificationsPhysiological contextHuman diseasesPhysiological roleM6ACatalytic componentFunctional relevanceCell linesM6A modulatorsDifferent cellsDisease conditionsTranscriptomeRecent advancesErasersRegulatorBindsModificationSENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications 2018, 9: 3157. PMID: 30089837, PMCID: PMC6082899, DOI: 10.1038/s41467-018-05676-6.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAntineoplastic AgentsAutoimmunityBasic-Leucine Zipper Transcription FactorsBone Marrow CellsCD4-Positive T-LymphocytesCell DifferentiationCell Line, TumorCell NucleusCysteine EndopeptidasesFemaleGene DeletionGene Expression ProfilingGene Expression RegulationHEK293 CellsHomeostasisHumansImmune ToleranceLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutPeptide HydrolasesReactive Oxygen SpeciesSumoylationT-Lymphocytes, RegulatoryConceptsRegulatory T cellsTreg cellsT cellsReactive oxygen speciesSUMO-specific protease 3T effector cell differentiationAntitumor T-cell responsesTreg cell-specific deletionT cell responsesEffector cell differentiationTreg cell stabilityCell-specific deletionT cell activationImmune toleranceTumor immunosuppressionAutoimmune symptomsImmune homeostasisRegulation of ROSRole of SENP3Cell activationCell responsesGene signatureProtease 3Pivotal regulatorNuclear export
2016
Recent advances in dynamic m6A RNA modification
Cao G, Li HB, Yin Z, Flavell RA. Recent advances in dynamic m6A RNA modification. Open Biology 2016, 6: 160003. PMID: 27249342, PMCID: PMC4852458, DOI: 10.1098/rsob.160003.Peer-Reviewed Original ResearchConceptsRNA modificationsHigh-throughput sequencing analysisRNA epigenetic modificationM6A RNA modificationRNA splicingEpigenetic modificationsBiological functionsSequencing analysisTranscriptomeRecent advancesDynamic regulation processRegulation processesFundamental rolePossible roleDemethylasesRelated diseasesSplicingMammalsErasersImmune responseRegulationModificationRoleCytogeneticsTypical features
2014
Resemble and Inhibit: When RLR Meets TGF-β
Zhu S, Li HB, Flavell RA. Resemble and Inhibit: When RLR Meets TGF-β. Molecular Cell 2014, 56: 719-720. PMID: 25526529, DOI: 10.1016/j.molcel.2014.12.010.Peer-Reviewed Original ResearchInflammasome activation and metabolic disease progression
Li HB, Jin C, Chen Y, Flavell RA. Inflammasome activation and metabolic disease progression. Cytokine & Growth Factor Reviews 2014, 25: 699-706. PMID: 25156419, DOI: 10.1016/j.cytogfr.2014.07.020.Peer-Reviewed Original ResearchConceptsObesity-associated metabolic diseasesCytokines IL-1βMetabolic stressInnate immune systemMetabolic disease progressionIL-18IL-1βWorldwide epidemicDisease progressionInflammasome activationMetabolic diseasesImmune systemCytosolic sensorsRecent evidenceInflammasomeNLRActivationDifferent tissuesMetabolic systems
2013
Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies
Li HB, Ohno K, Gui H, Pirrotta V. Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies. PLOS Genetics 2013, 9: e1003436. PMID: 23637616, PMCID: PMC3630138, DOI: 10.1371/journal.pgen.1003436.Peer-Reviewed Original ResearchConceptsPolycomb response elementsPolycomb target genesPolycomb bodiesTranscription factoriesTarget genesSpecialized transcription factoriesAbsence of CTCFInsulator protein CTCFInsulator proteinsPolycomb proteinsPolycomb groupProtein CTCFActive genesChromosomal contextCellular memoryEnhancer specificityGenomic clustersStable associationResponse elementGenesDifferent nuclear structuresTrithoraxCTCFActive stateCritical role
2011
A view of nuclear Polycomb bodies
Pirrotta V, Li HB. A view of nuclear Polycomb bodies. Current Opinion In Genetics & Development 2011, 22: 101-109. PMID: 22178420, PMCID: PMC3329586, DOI: 10.1016/j.gde.2011.11.004.Peer-Reviewed Original Research