2019
hnRNPA2B1: a nuclear DNA sensor in antiviral immunity
Zhang X, Flavell RA, Li HB. hnRNPA2B1: a nuclear DNA sensor in antiviral immunity. Cell Research 2019, 29: 879-880. PMID: 31471560, PMCID: PMC6889404, DOI: 10.1038/s41422-019-0226-8.Peer-Reviewed Original Research
2018
cGAS activation in phased droplets
Liu Y, Li HB, Flavell RA. cGAS activation in phased droplets. Cell Research 2018, 28: 967-968. PMID: 30218060, PMCID: PMC6170418, DOI: 10.1038/s41422-018-0087-6.Peer-Reviewed Original Research
2016
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 2016, 354: 765-768. PMID: 27846608, PMCID: PMC5640175, DOI: 10.1126/science.aaf7532.Peer-Reviewed Original ResearchConceptsCell deathDNA sensor AIM2New therapeutic targetsCaspase-1-dependent deathIntestinal epithelial cellsBone marrow cellsGastrointestinal syndromeTissue injuryInflammasome activationGastrointestinal tractRadiation-induced cell deathRadiation-induced DNA damageTherapeutic targetAcute exposureBone marrowChemotherapeutic agentsMarrow cellsRadiation exposureAIM2Massive cell deathEpithelial cellsHematopoietic failureDeathMolecular mechanismsDNA damageChromosome Conformation Capture in Drosophila
Li HB. Chromosome Conformation Capture in Drosophila. Methods In Molecular Biology 2016, 1480: 207-212. PMID: 27659987, DOI: 10.1007/978-1-4939-6380-5_18.Peer-Reviewed Original ResearchConceptsDNA-DNA interactionsChromosome conformation capture techniquesChromosome conformation captureInsulator proteinsConformation captureThree-dimensional structureChromatin fibersTemporal regulationRegulatory proteinsGene expressionDrosophilaChromatinProteinCapture techniquesImportant roleGenesPCGNucleusRegulationExpressionInteraction