2024
Leveraging Functional Annotations Improves Cross-Population Genetic Risk Prediction
Ye Y, Xu L, Zhao H. Leveraging Functional Annotations Improves Cross-Population Genetic Risk Prediction. ICSA Book Series In Statistics 2024, 453-471. DOI: 10.1007/978-3-031-50690-1_18.Peer-Reviewed Original ResearchPolygenic risk scoresFunctional annotationGenetic risk predictionStandard PRSPost-GWAS analysisPolygenic risk score modelCross-population predictionNon-European populationsGenetic resultsGenetic studiesRisk predictionCross populationsAnnoPredPRS methodsUK BiobankAnnotationRisk scoreTraits/diseasesLDpredPopulationP+TPoor transferBiobankBayesian framework
2019
Improving Genetic Association Analysis through Integration of Functional Annotations of the Human Genome
Lu Q, Zhao H. Improving Genetic Association Analysis through Integration of Functional Annotations of the Human Genome. 2019, 679-30. DOI: 10.1002/9781119487845.ch24.Peer-Reviewed Original ResearchGenome-wide association studiesFunctional annotationHuman genomeAssociation analysisAnnotation dataFunctional annotation dataPost-GWAS analysisSummary association statisticsGenetic association analysisGWAS findingsGWAS dataIntegrative analysisAssociation studiesComplex diseasesAssociation statisticsGenetic associationGenomeComputational methodsAnnotationTraitsDirect applicationStatistical powerMost diseasesInterpretable metricsTens of thousands